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Andrew J. Cole
Researcher at Harvard University
Publications - 267
Citations - 12422
Andrew J. Cole is an academic researcher from Harvard University. The author has contributed to research in topics: Epilepsy & Epilepsy surgery. The author has an hindex of 48, co-authored 255 publications receiving 10575 citations. Previous affiliations of Andrew J. Cole include University of Wisconsin-Madison & Columbia University.
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Journal ArticleDOI
Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation
TL;DR: It is found that high-frequency stimulation of the perforant path-granule cell (pp-gc) synapse markedly increases zif/268 messenger RNA levels in the ipsilateral granule cell neurons; mRNA of c-fos, c-jun and jun-B is less consistently increased.
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Two‐year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: Final results of the RNS System Pivotal trial
Christianne N. Heck,David King-Stephens,Andrew Massey,Dileep Nair,Barbara C. Jobst,Gregory L. Barkley,Vicenta Salanova,Andrew J. Cole,Michael C. Smith,Ryder P. Gwinn,Christopher Skidmore,Paul C. Van Ness,Gregory K. Bergey,Yong D. Park,Ian Miller,Eric B. Geller,Paul Rutecki,Richard S. Zimmerman,David C. Spencer,Alica M. Goldman,Jonathan C. Edwards,James W. Leiphart,Robert E. Wharen,James Fessler,Nathan B. Fountain,Gregory A. Worrell,Robert E. Gross,Stephan Eisenschenk,Robert B. Duckrow,Lawrence J. Hirsch,Carl W. Bazil,Cormac A. O'Donovan,Felice T. Sun,Tracy A. Courtney,Cairn G. Seale,Martha J. Morrell +35 more
TL;DR: To demonstrate the safety and effectiveness of responsive stimulation at the seizure focus as an adjunctive therapy to reduce the frequency of seizures in adults with medically intractable partial onset seizures arising from one or two seizure foci.
Journal ArticleDOI
Long-term treatment with responsive brain stimulation in adults with refractory partial seizures
Gregory K. Bergey,Martha J. Morrell,Eli M. Mizrahi,Alica M. Goldman,David King-Stephens,Dileep Nair,Shraddha Srinivasan,Barbara C. Jobst,Robert E. Gross,Donald C. Shields,Gregory L. Barkley,Vicenta Salanova,Piotr W. Olejniczak,Andrew J. Cole,Sydney S. Cash,Katherine H. Noe,Robert E. Wharen,Gregory A. Worrell,Anthony M. Murro,Jonathan C. Edwards,Michael Duchowny,David C. Spencer,Michael C. Smith,Eric B. Geller,Ryder P. Gwinn,Christopher Skidmore,Stephan Eisenschenk,Michel J. Berg,Christianne N. Heck,Paul C. Van Ness,Nathan B. Fountain,Paul Rutecki,Andrew Massey,Cormac A. O'Donovan,Douglas Labar,Robert B. Duckrow,Lawrence J. Hirsch,Tracy A. Courtney,Felice T. Sun,Cairn G. Seale +39 more
TL;DR: This study provides Class IV evidence that for adults with medically refractory partial onset seizures, responsive direct cortical stimulation reduces seizures and improves quality of life over a mean follow-up of 5.4 years.
Journal ArticleDOI
The Future of Aquatic Protein: Implications for Protein Sources in Aquaculture Diets
Katheline Hua,Jennifer M. Cobcroft,Andrew J. Cole,Kelly Condon,Dean R. Jerry,Arnold Mangott,Christina Praeger,Matthew J. Vucko,Chaoshu Zeng,Kyall R. Zenger,Jan M. Strugnell +10 more
TL;DR: There is considerable scope for improved efficiency in fed aquaculture and the development and optimization of alternative protein sources for aquafeeds to ensure a socially and environmentally sustainable future for the Aquaculture industry.
Journal ArticleDOI
Convulsant-induced increase in transcription factor messenger RNAs in rat brain
TL;DR: It is hypothesized that the increase in mRNAs of four putative transcription factor genes, zif/268, c-jun, jun-B, and c-fos, in the brain is part of a programmed genomic response of neurons to intense stimulation, which is analogous to the genomicresponse of nonneuronal cells to growth factors.