Y
Yi Zhong
Researcher at Huazhong University of Science and Technology
Publications - 21
Citations - 525
Yi Zhong is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Mitochondrial DNA & Head and neck squamous-cell carcinoma. The author has an hindex of 10, co-authored 20 publications receiving 441 citations.
Papers
More filters
Journal ArticleDOI
A long-term high-fat diet increases oxidative stress, mitochondrial damage and apoptosis in the inner ear of d-galactose-induced aging rats
TL;DR: It is demonstrated that HFD may induce oxidative stress, mitochondrial damage and apoptosis in the inner ear, and it provided evidence regarding the link between HFD and an increased risk of age-related hearing loss.
Journal ArticleDOI
Age-related changes in the central auditory system: comparison of D-galactose-induced aging rats and naturally aging rats.
TL;DR: Observations suggest that age-related central auditory dysfunction and its corresponding pathological changes are present in both naturally aging rats and the D-gal mimetic aging model.
Journal ArticleDOI
Increased mitochondrial DNA damage and decreased base excision repair in the auditory cortex of D-galactose-induced aging rats.
TL;DR: The authors' data showed that mtDNA 4834 bp deletion and TUNEL-positive cells were significantly increased and the expression of pol γ and OGG1 were remarkably down-regulated in the auditory cortex in d-gal-treated rats compared to control rats.
Journal ArticleDOI
Age-related changes in mitochondrial antioxidant enzyme Trx2 and TXNIP-Trx2-ASK1 signal pathways in the auditory cortex of a mimetic aging rat model: changes to Trx2 in the auditory cortex.
Haiying Sun,Yujuan Hu,Xueyan Zhao,Yi Zhong,Lingling Zeng,Xubo Chen,Jie Yuan,Jing Wu,Yu Sun,Wen Kong,Weijia Kong,Weijia Kong +11 more
TL;DR: The results indicated that changes in Trx2 and the TXNIP–Trx2–ASK1 signal pathway may participate in the pathogenesis of central presbycusis.
Journal ArticleDOI
Mitochondrial transcription factor A overexpression and base excision repair deficiency in the inner ear of rats with d‐galactose‐induced aging
Yi Zhong,Yujuan Hu,Bei Chen,Bei Chen,Wei Peng,Yu Sun,Yang Yang,Xueyan Zhao,Guo-run Fan,Xiang Huang,Weijia Kong +10 more
TL;DR: The data suggest that mitochondrial base excision repair capacity deficiency and an increase in mtDNA replication resulting from mitochondrial transcription factor A overexpression may contribute to the accumulation of mtDNA deletions in the inner ear during aging.