Y
Yifan Zhou
Researcher at Huazhong University of Science and Technology
Publications - 39
Citations - 7655
Yifan Zhou is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 12, co-authored 23 publications receiving 5116 citations. Previous affiliations of Yifan Zhou include Tongji Medical College.
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Journal ArticleDOI
Semaphorin-3A protects against neointimal hyperplasia after vascular injury.
Jie-Hong Wu,Yifan Zhou,Candong Hong,An-qi Chen,Yan Luo,Ling Mao,Yuan-Peng Xia,Quan-Wei He,Huijuan Jin,Ming Huang,Yanan Li,Bo Hu +11 more
TL;DR: It is found that semaphorin-3A (Sema3A) was significantly downregulated in VSMCs during neointimal hyperplasia after vascular injury in mice and in human atherosclerotic plaques.
Journal ArticleDOI
Sema3E/PlexinD1 signaling inhibits postischemic angiogenesis by regulating endothelial DLL4 and filopodia formation in a rat model of ischemic stroke
Yifan Zhou,An-qi Chen,Jie-Hong Wu,Ling Mao,Yuan-Peng Xia,Huijuan Jin,Quan-Wei He,Qing Robert Miao,Zhenyu Yue,Xiu-Li Liu,Ming Huang,Yanan Li,Bo Hu +12 more
TL;DR: This study reveals that Sema3E/PlexinD1 signaling, which suppressed endothelial DLL4 expression, cell motility, and filopodia formation, is expected to be a novel druggable target for angiogenesis during poststroke progression.
Journal ArticleDOI
pH-Sensitive, Cerebral Vasculature-Targeting Hydroxyethyl Starch Functionalized Nanoparticles for Improved Angiogenesis and Neurological Function Recovery in Ischemic Stroke.
Hang Yang,Yan Luo,Hang Hu,Sibo Yang,Yanan Li,Huijuan Jin,Shengcai Chen,Quan-Wei He,Candong Hong,Jie-Hong Wu,Yan Wan,Man Li,Zifu Li,Xiangliang Yang,Ying Su,Yifan Zhou,Bo Hu +16 more
TL;DR: In this paper, a dual-targeted therapeutic strategy is reported to enable pH-sensitive drug release and allow cerebral ischemia targeting to improve stroke therapeutic efficacy, which is achieved by surface conjugation of Pro-His-Ser-Arg-Asn (PHSRN) peptides which binds to integrin α5 β1 enriched in the cerebral vasculature of ischemic tissue.
Journal ArticleDOI
Intravenous thrombolysis for acute ischaemic stroke during COVID-19 pandemic in Wuhan, China: a multicentre, retrospective cohort study.
Yifan Zhou,Candong Hong,Jiang Chang,Yuan-Peng Xia,Huijuan Jin,Yanan Li,Ling Mao,Yong Wang,Lei Zhang,Chunlian Pan,Jichuan Hu,Ming Huang,David Z. Wang,Shengcai Chen,Bo Hu +14 more
TL;DR: A retrospective analysis of two groups of patients with AIS received intravenous tissue plasminogen activator (tPA) during 1 January to 30 Marchh of 2019 and 2020 in four hospitals in Wuhan, Hubei and four hospitals continuously received emergency cases during COVID-19 epidemic.
Journal ArticleDOI
The role of semaphorins in small vessels of the eye and brain.
TL;DR: This review focuses on the regulatory effects of semaphorins on the cell components of the vessel wall and their potential roles in microvascular diseases, especially in the retina and cerebral small vessel.