Yuan-Peng Xia

TL;DR: Anti-TNFα (infliximab, a potent clinically used drug) treatment significantly ameliorate endothelial necroptosis, BBB destruction and improve stroke outcomes and suggest infliximab might serve as a potential drug for stroke therapy.

TL;DR: Light is shed on the role of LncRNA TUG1 as a miRNA sponge for ischemic stroke, possibly providing a new therapeutic target in stroke.

TL;DR: It is shown that lncRNA myocardial infarction associated transcript (MIAT) was markedly elevated in the serum of patients with symptoms of vulnerable atherosclerotic plaque and the macrophages of necrotic cores in an advanced atherosclerosis mouse model.

TL;DR: It is demonstrated that activation of SHH signaling protects cortical neurons against oxidative stress and suggest a potential role of SHh for the clinic treatments of brain ischemia and neurodegenerative disorders.

TL;DR: It is suggested that, under ischemic insults, Shh triggers Ang- 1 production predominantly in astrocytes, and the secreted Ang-1 acts on BMECs, thereby upregulating ZO-1 and occludin to repair the tight junction and ameliorate the brain edema and BBB leakage.