Y
Yijun Yin
Researcher at Agency for Science, Technology and Research
Publications - 11
Citations - 1996
Yijun Yin is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Embryonic stem cell & Exosome. The author has an hindex of 10, co-authored 11 publications receiving 1597 citations. Previous affiliations of Yijun Yin include National University of Singapore.
Papers
More filters
Journal ArticleDOI
Mesenchymal stem cell: An efficient mass producer of exosomes for drug delivery☆
TL;DR: Of the cell types known to produce exosomes, the readily available proliferative, immunosuppressive and clinically tested human mesenchymal stem cell (MSC) is the most prolific producer.
Journal ArticleDOI
Mesenchymal stem cells secrete immunologically active exosomes.
TL;DR: It is demonstrated that MSC exosome, a secreted membrane vesicle, is immunologically active and induced polymyxin-resistant, MYD88-dependent secreted embryonic alkaline phosphatase (SEAP) expression in a THP1-Xblue reporter cell line.
Journal ArticleDOI
Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs.
Tiansheng Chen,Fatih Arslan,Yijun Yin,Soon Sim Tan,Ruenn Chai Lai,Ruenn Chai Lai,Andre Choo,Jayanthi Padmanabhan,Chuen Neng Lee,Dominique P.V. de Kleijn,Sai Kiang Lim +10 more
TL;DR: It is demonstrated that MYC transformation is a practical strategy in ensuring an infinite supply of cells for the production of exosomes in the milligram range as either therapeutic agents or delivery vehicles and reduces production costs.
Journal ArticleDOI
Therapeutic MSC exosomes are derived from lipid raft microdomains in the plasma membrane
Soon Sim Tan,Yijun Yin,Tricia Lee,Ruenn Chai Lai,Ronne Wee Yeh Yeo,Bin Zhang,Andre Choo,Sai Kiang Lim +7 more
TL;DR: It is demonstrated that MSC exosomes are derived from endocytosed lipid rafts and that their protein cargo includes exosome-associated proteins CD81, CD9, Alix and Tsg101.
Journal ArticleDOI
Immunotherapeutic potential of extracellular vesicles.
TL;DR: The immunological activities of exosomes affect both innate and adaptive immunity and include antigen presentation, Tcell activation, T cell polarization to regulatory T cells, immune suppression, and anti-inflammation, and carry much immunotherapeutic potential as a therapeutic agent and a therapeutic target.