D
Dominique P.V. de Kleijn
Researcher at University Medical Center Utrecht
Publications - 84
Citations - 10315
Dominique P.V. de Kleijn is an academic researcher from University Medical Center Utrecht. The author has contributed to research in topics: Medicine & Myocardial infarction. The author has an hindex of 26, co-authored 63 publications receiving 8726 citations. Previous affiliations of Dominique P.V. de Kleijn include Utrecht University & National University of Singapore.
Papers
More filters
Journal ArticleDOI
Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury.
Ruenn Chai Lai,Fatih Arslan,May May Lee,Newman Siu Kwan Sze,Andre Choo,Tiansheng Chen,Manuel Salto-Tellez,Leo Timmers,Chuen Neng Lee,Reida El Oakley,Gerard Pasterkamp,Dominique P.V. de Kleijn,Sai Kiang Lim +12 more
TL;DR: The novel role of exosomes highlights a new perspective into intercellular mediation of tissue injury and repair, and engenders novel approaches to the development of biologics for tissue repair.
Journal ArticleDOI
Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper
Thomas Lener,Mario Gimona,Ludwig Aigner,Verena Börger,Edit I. Buzás,Giovanni Camussi,Nathalie Chaput,Devasis Chatterjee,Felipe A. Court,Hernando A. del Portillo,Lorraine O'Driscoll,Stefano Fais,Juan M. Falcón-Pérez,Ursula Felderhoff-Mueser,Lorenzo Fraile,Yong Song Gho,André Görgens,Ramesh C. Gupta,An Hendrix,Dirk M. Hermann,Andrew F. Hill,Fred H. Hochberg,Peter A. Horn,Dominique P.V. de Kleijn,Lambros Kordelas,Boris W. Kramer,Eva-Maria Krämer-Albers,Sandra Laner-Plamberger,Saara Laitinen,Tommaso Leonardi,Magdalena J. Lorenowicz,Sai Kiang Lim,Jan Lötvall,Casey A. Maguire,Antonio Marcilla,Irina Nazarenko,Takahiro Ochiya,Tushar Patel,Shona Pedersen,Gabriella Pocsfalvi,Stefano Pluchino,Peter J. Quesenberry,Ilona G. Reischl,Francisco J. Rivera,Ralf Sanzenbacher,Katharina Schallmoser,Ineke Slaper-Cortenbach,Dirk Strunk,Torsten Tonn,Pieter Vader,Pieter Vader,Bas W.M. van Balkom,Marca H. M. Wauben,Samir El Andaloussi,Samir El Andaloussi,Clotilde Théry,Eva Rohde,Bernd Giebel +57 more
TL;DR: In this paper, the authors summarize recent developments and the current knowledge of extracellular vesicles (EVs) and discuss safety and regulatory requirements that must be considered for pharmaceutical manufacturing and clinical application.
Journal ArticleDOI
Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury
Fatih Arslan,Ruenn Chai Lai,Ruenn Chai Lai,Mirjam B. Smeets,Lars Akeroyd,Andre Choo,Eissa N. E. Aguor,Leo Timmers,Harold V.M. van Rijen,Pieter A. Doevendans,Gerard Pasterkamp,Sai Kiang Lim,Dominique P.V. de Kleijn +12 more
TL;DR: This study shows that intact exosomes restore bioenergetics, reduce oxidative stress and activate pro-survival signaling, thereby enhancing cardiac function and geometry after myocardial I/R injury, and Hence, mesenchymal stem cell-derived exosome are a potential adjuvant to reperfusion therapy for my cardiac infarction.
Journal ArticleDOI
Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium.
Leo Timmers,Sai Kiang Lim,Fatih Arslan,Jeffrey S. Armstrong,Imo E. Hoefer,Pieter A. Doevendans,Jan J. Piek,Reida El Oakley,Andre Choo,Chuen Neng Lee,Gerard Pasterkamp,Dominique P.V. de Kleijn +11 more
TL;DR: The data identify human MSC-CM as a promising therapeutic option to reduce myocardial infarct size in patients with acute MI and suggest that the use of stem cell secretions could extend the applicability of stem cells for therapeutic purposes.
Journal ArticleDOI
Frameshift Mutants of β Amyloid Precursor Protein and Ubiquitin-B in Alzheimer's and Down Patients
Fred W. van Leeuwen,Dominique P.V. de Kleijn,Helma H. van den Hurk,Andrea Neubauer,M. A. F. Sonnemans,Jacqueline A. Sluijs,Soner Köycü,Ravindra D. J. Ramdjielal,Ahmad Salehi,Gerard J.M. Martens,Frank Grosveld,J. Peter H. Burbach,Elly M. Hol +12 more
TL;DR: The cerebral cortex of Alzheimer's and Down syndrome patients is characterized by the presence of protein deposits in neurofibrillary tangles, neuritic plaques, and neuropil threads.