F
Fatih Arslan
Researcher at Utrecht University
Publications - 58
Citations - 7936
Fatih Arslan is an academic researcher from Utrecht University. The author has contributed to research in topics: Myocardial infarction & Reperfusion injury. The author has an hindex of 28, co-authored 52 publications receiving 6747 citations. Previous affiliations of Fatih Arslan include University Medical Center Utrecht & University of Nevada, Reno.
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Journal ArticleDOI
Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury.
Ruenn Chai Lai,Fatih Arslan,May May Lee,Newman Siu Kwan Sze,Andre Choo,Tiansheng Chen,Manuel Salto-Tellez,Leo Timmers,Chuen Neng Lee,Reida El Oakley,Gerard Pasterkamp,Dominique P.V. de Kleijn,Sai Kiang Lim +12 more
TL;DR: The novel role of exosomes highlights a new perspective into intercellular mediation of tissue injury and repair, and engenders novel approaches to the development of biologics for tissue repair.
Journal ArticleDOI
Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury
Fatih Arslan,Ruenn Chai Lai,Ruenn Chai Lai,Mirjam B. Smeets,Lars Akeroyd,Andre Choo,Eissa N. E. Aguor,Leo Timmers,Harold V.M. van Rijen,Pieter A. Doevendans,Gerard Pasterkamp,Sai Kiang Lim,Dominique P.V. de Kleijn +12 more
TL;DR: This study shows that intact exosomes restore bioenergetics, reduce oxidative stress and activate pro-survival signaling, thereby enhancing cardiac function and geometry after myocardial I/R injury, and Hence, mesenchymal stem cell-derived exosome are a potential adjuvant to reperfusion therapy for my cardiac infarction.
Journal ArticleDOI
Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium.
Leo Timmers,Sai Kiang Lim,Fatih Arslan,Jeffrey S. Armstrong,Imo E. Hoefer,Pieter A. Doevendans,Jan J. Piek,Reida El Oakley,Andre Choo,Chuen Neng Lee,Gerard Pasterkamp,Dominique P.V. de Kleijn +11 more
TL;DR: The data identify human MSC-CM as a promising therapeutic option to reduce myocardial infarct size in patients with acute MI and suggest that the use of stem cell secretions could extend the applicability of stem cells for therapeutic purposes.
Journal ArticleDOI
Prognostic value of fractional flow reserve: linking physiologic severity to clinical outcomes.
Nils P. Johnson,Gabor G. Toth,Dejian Lai,Hongjian Zhu,Göksel Açar,Pierfrancesco Agostoni,Yolande Appelman,Fatih Arslan,Emanuele Barbato,Shao-Liang Chen,Luigi Di Serafino,Antonio J. Domínguez-Franco,Patrick Dupouy,Ali Metin Esen,Ozlem Esen,Michalis Hamilos,Kohichiro Iwasaki,Lisette Okkels Jensen,Manuel F. Jiménez-Navarro,Demosthenes G. Katritsis,Sinan Altan Kocaman,Bon-Kwon Koo,Ramón López-Palop,Jeffrey D. Lorin,Louis H. Miller,Olivier Muller,Chang Wook Nam,Niels Oud,Etienne Puymirat,Johannes Rieber,Gilles Rioufol,Josep Rodés-Cabau,Steven P. Sedlis,Yasuchika Takeishi,Pim A.L. Tonino,Eric Van Belle,Edoardo Verna,Gerald S. Werner,William F. Fearon,Nico H.J. Pijls,Bernard De Bruyne,K. Lance Gould +41 more
TL;DR: FFR demonstrates a continuous and independent relationship with subsequent outcomes, modulated by medical therapy versus revascularization, such that lower FFR values confer a higher risk and therefore receive larger absolute benefits fromRevascularization.
Journal ArticleDOI
Proteolytic Potential of the MSC Exosome Proteome: Implications for an Exosome-Mediated Delivery of Therapeutic Proteasome
Ruenn Chai Lai,Soon Sim Tan,Bao Ju Teh,Siu Kwan Sze,Fatih Arslan,Dominique P.V. de Kleijn,Andre Choo,Sai Kiang Lim +7 more
TL;DR: 20S proteasome is a candidate exosome protein that could synergize with other constituents to ameliorate tissue damage and be correlated with a modest but significant reduction in oligomerized protein in a mouse model of myocardial infarction.