Y
Ying Chen
Researcher at Zhejiang University
Publications - 8
Citations - 436
Ying Chen is an academic researcher from Zhejiang University. The author has contributed to research in topics: Ischemia & Neuroprotection. The author has an hindex of 7, co-authored 8 publications receiving 288 citations. Previous affiliations of Ying Chen include Sir Run Run Shaw Hospital.
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Journal ArticleDOI
BNIP3L/NIX-mediated mitophagy protects against ischemic brain injury independent of PARK2.
Yang Yuan,Yanrong Zheng,Xiangnan Zhang,Ying Chen,Xiaoli Wu,Jiaying Wu,Zhe Shen,Lei Jiang,Lu Wang,Wei Yang,Jianhong Luo,Zheng-Hong Qin,Weiwei Hu,Zhong Chen +13 more
TL;DR: The involvement of BNIP3L/NIX in cerebral ischemia-reperfusion (I-R)-induced mitophagy is identified and insights into mitochondrial quality control in ischemic stroke are offered.
Journal ArticleDOI
PARK2-dependent mitophagy induced by acidic postconditioning protects against focal cerebral ischemia and extends the reperfusion window
Zhe Shen,Yanrong Zheng,Jiaying Wu,Ying Chen,Xiaoli Wu,Yiting Zhou,Yang Yuan,Shou-sheng Lu,Lei Jiang,Zheng-Hong Qin,Zhong Chen,Weiwei Hu,Xiangnan Zhang +12 more
TL;DR: It is found that PARK2-dependent APC-induced mitophagy renders the brain resistant to ischemic injury, and APC treatment could be a favorable strategy to extend the thrombolytic time window for stroke therapy.
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Histidine provides long-term neuroprotection after cerebral ischemia through promoting astrocyte migration
Rujia Liao,Lei Jiang,Rong-rong Wang,Hua-Wei Zhao,Ying Chen,Ya Li,Lu Wang,Li-Yong Jie,Yu-Dong Zhou,Xiangnan Zhang,Zhong Chen,Weiwei Hu +11 more
TL;DR: The data indicated that a dose/stage-dependent histidine treatment, mediated by H2 receptor, promoted astrocyte migration towards the infarct core, which benefited long-term post-cerebral ischemia neurological recovery.
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Interleukin-1β impedes oligodendrocyte progenitor cell recruitment and white matter repair following chronic cerebral hypoperfusion.
Yiting Zhou,Jing Zhang,Lu Wang,Ying Chen,Yushan Wan,Yang He,Lei Jiang,Jing Ma,Rujia Liao,Xiangnan Zhang,Liyun Shi,Zheng-Hong Qin,Yu-Dong Zhou,Zhong Chen,Weiwei Hu +14 more
TL;DR: The results suggest that IL-1β during the early stages following chronic cerebral hypoperfusion impedes OPC recruitment viaIL-1R1, which inhibits white matter repair and functional recovery and may have potential uses in the treatment of SIVD.
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Early treatment of minocycline alleviates white matter and cognitive impairments after chronic cerebral hypoperfusion.
Jing Ma,Jing Zhang,Jing Zhang,Wei Wei Hou,Xiao Hua Wu,Ru Jia Liao,Ying Chen,Zhe Wang,Xiang Nan Zhang,Li san Zhang,Yu-Dong Zhou,Zhong Chen,Wei Wei Hu +12 more
TL;DR: There is direct evidence that early treatment is critical for minocycline to alleviate white matter and cognitive impairments after chronic cerebral hypoperfusion, which may be due to its robust effects on OPC proliferation and mature oligodendrocyte loss.