Ying-Jie Li

TL;DR: In this paper, the authors summarize advanced studies of autophagy in multidrug resistance (MDR) tumors, including the variable role of auto-gathering in MDR cancer cells.

TL;DR: This review critically describes the recent research on isolation, synthesis, and derivatization of BA and its natural analogs betulin and 23‐hydroxybetulinic acid and focuses on the current knowledge of antitumor properties, combination treatments, and pharmacological mechanisms of these compounds.

TL;DR: B5G1, a new derivative of BA, induces cell death in multidrug resistant cancer cells HepG2/ADM and MCF-7/ADR through mitochondrial-apoptosis pathway and provides the first demonstration that B5G 1, as a novel mitophagy inducer, has the potential to be developed into a drug candidate for treating multidrog resistant cancer.

TL;DR: This study assessed the mechanistic effect of cabozantinib on the reversal of P‐glycoprotein (P‐gp)‐mediated multidrug resistance (MDR).

TL;DR: It is reported that arenobufagin blocked the transition from G2 to M phase of cell cycle through inhibiting the activation of CDK1-Cyclin B1 complex; the tumor suppressor p53 contributed to sustaining arrest at the G2 phase of the cell cycle in hepatocellular carcinoma (HCC) cells.