Y
Ying Kang
Researcher at University of Iowa
Publications - 8
Citations - 540
Ying Kang is an academic researcher from University of Iowa. The author has contributed to research in topics: Mechanism of action & Vinyl ether. The author has an hindex of 5, co-authored 8 publications receiving 490 citations.
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Journal ArticleDOI
Improved Procedure for the Oxidative Cleavage of Olefins by OsO4−NaIO4
TL;DR: It is found that the addition of 2,6-lutidine can suppress the side reactions and dramatically improve the yield of this classic reaction.
Journal ArticleDOI
OSW-1: a Natural Compound With Potent Anticancer Activity and a Novel Mechanism of Action
Yan Zhou,Celia Garcia-Prieto,Dennis A. Carney,Rui-Hua Xu,Helene Pelicano,Ying Kang,Wensheng Yu,Changgang Lou,Seiji Kondo,Jinsong Liu,David Harris,Zeev Estrov,Michael J. Keating,Zhendong Jin,Peng Huang +14 more
TL;DR: In vitro analysis revealed that OSW-1 effectively killed primary leukemia cells from chronic lymphocytic leukemia patients with disease refractory to fludarabine, and this compound is worthy of further investigation for its potential to overcome drug resistance.
Journal ArticleDOI
Effective killing of leukemia cells by the natural product OSW-1 through disruption of cellular calcium homeostasis
Celia Garcia-Prieto,Kausar Begam Riaz Ahmed,Kausar Begam Riaz Ahmed,Zhao Chen,Zhao Chen,Yan Zhou,Naima Hammoudi,Ying Kang,Changgang Lou,Yan Mei,Zhendong Jin,Peng Huang +11 more
TL;DR: The extremely potent activity of OSW-1 against leukemia cells and its unique mechanism of action suggest that this compound may be potentially useful in the treatment of leukemia.
Journal ArticleDOI
Negishi Coupling between α-Alkyl(aryl)thio Vinyl Zinc Chloride and α-Bromo Vinyl Ether: A Convergent Synthesis of 2-Alkoxy-3-alkyl(aryl)thiobuta-1,3-dienes1
TL;DR: In this article, a convergent approach for the stereoselective synthesis of 2-alkoxy-3-alkyl(aryl)thiobuta-1,3-dienes has been developed.
Journal ArticleDOI
Synthesis of biotinylated OSW-1.
TL;DR: OSW-1 is a highly potent anticancer natural saponin with an unknown mode of action and to determine its cellular target(s) biotinylated OSW- 1 was successfully synthesized in nine steps.