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Ying Wang
Researcher at AbbVie
Publications - 50
Citations - 1446
Ying Wang is an academic researcher from AbbVie. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 18, co-authored 47 publications receiving 1166 citations.
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Journal ArticleDOI
Structure−Activity Relationship Studies on a Series of Novel, Substituted 1-Benzyl-5-phenyltetrazole P2X7 Antagonists
Derek W. Nelson,Robert J. Gregg,Michael E. Kort,Arturo Perez-Medrano,Voight Eric,Ying Wang,George K. Grayson,Marian T. Namovic,Diana L. Donnelly-Roberts,Wende Niforatos,Prisca Honore,Michael F. Jarvis,Connie R. Faltynek,William A. Carroll +13 more
TL;DR: 1-Benzyl-5-aryltetrazoles were discovered to be novel antagonists for the P2X(7) receptor and advanced to efficacy studies in a model of neuropathic pain where significant reversal of mechanical allodynia was observed at doses that did not affect motor coordination.
Journal ArticleDOI
Selective C(sp3)−H aerobic oxidation enabled by decatungstate photocatalysis in flow
Gabriele Laudadio,Sebastian Govaerts,Ying Wang,Davide Ravelli,Hannes Fiepko Koolman,Hannes Fiepko Koolman,Maurizio Fagnoni,Stevan W. Djuric,Timothy Noël +8 more
TL;DR: In this paper, a mild and selective C(sp3 )-H aerobic oxidation enabled by decatungstate photocatalysis has been developed, which allows for the oxidation of both activated and unactivated C-H bonds.
Journal ArticleDOI
A simple and efficient one step synthesis of benzoxazoles and benzimidazoles from carboxylic acids
TL;DR: In this paper, the use of commercially available PS-PPh3 resin combined with microwave heating delivered a variety of benzoxazoles and benzimidazoles in high yields and purities.
Journal ArticleDOI
Rapid and efficient synthesis of 1,2,4-oxadiazoles utilizing polymer-supported reagents under microwave heating.
TL;DR: The use of commercially available polymer-supported reagents combined with microwave heating resulted in high yields and purities of the product 1,2,4-oxadiazoles in an expeditious manner.
Journal ArticleDOI
[3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors.
Diana L. Donnelly-Roberts,Marian T. Namovic,Bruce Surber,Srirajan Vaidyanathan,Arturo Perez-Medrano,Ying Wang,William A. Carroll,Michael F. Jarvis +7 more
TL;DR: It is demonstrated that A-804598 is one of the most potent and selective antagonists for mammalian P2X7 receptors described to date and [3H]A-80 4598 is a high affinity antagonist radioligand that specifically labels rat P2x7 receptors.