Yoel Sadovsky

TL;DR: The integrated acoustofluidic device offers a unique approach to investigate the role of exosomes in the onset and progression of human diseases with potential applications in health monitoring, medical diagnosis, targeted drug delivery, and personalized medicine.

TL;DR: An analysis of NGFI-A-deficient mice derived from embryonic stem cells demonstrated female infertility that was secondary to LH-β deficiency, and ovariectomy led to increased amounts of FSH-β but not RH messenger RNA, which suggested a pituitary defect.

TL;DR: It is discovered that PHT cells from full-term placentas are refractory to ZIKV infection, and the data suggest that for ZikV to access the fetal compartment, it must evade restriction by trophoblast-derived IFNλ1 and other trophOBlast-specific antiviral factors and/or use alternative strategies to cross the placental barrier.

TL;DR: Results confirm that SF-1 is an important regulator of adrenal and gonadal development, but its regulation of steroid hydroxylase expression in vivo remains to be established.

TL;DR: This work shows that cultured primary human placental trophoblasts are highly resistant to infection by a number of viruses and confer this resistance to nonplacental recipient cells by exosome-mediated delivery of specific microRNAs (miRNAs) to directly communicate with placental or maternal target cells and regulate their immunity to viral infections.