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Nicholas J. Lennemann
Researcher at University of Pittsburgh
Publications - 25
Citations - 1536
Nicholas J. Lennemann is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Viral replication & Virus. The author has an hindex of 15, co-authored 21 publications receiving 1279 citations. Previous affiliations of Nicholas J. Lennemann include University of Alabama at Birmingham & University of Iowa.
Papers
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Journal ArticleDOI
Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection
Avraham Bayer,Nicholas J. Lennemann,Yingshi Ouyang,John C. Bramley,Stefanie A. Morosky,Ernesto Torres De Azeved Marques,Ernesto Torres De Azeved Marques,Sara Cherry,Yoel Sadovsky,Carolyn B. Coyne +9 more
TL;DR: It is discovered that PHT cells from full-term placentas are refractory to ZIKV infection, and the data suggest that for ZikV to access the fetal compartment, it must evade restriction by trophoblast-derived IFNλ1 and other trophOBlast-specific antiviral factors and/or use alternative strategies to cross the placental barrier.
Journal ArticleDOI
T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus
Andrew S. Kondratowicz,Nicholas J. Lennemann,Patrick L. Sinn,Robert A. Davey,Catherine L. Hunt,Sven Moller-Tank,David K. Meyerholz,Paul D. Rennert,Robert F. Mullins,Melinda A. Brindley,Lindsay M Sandersfeld,Kathrina Quinn,Melodie L. Weller,Paul B. McCray,John A. Chiorini,Wendy Maury +15 more
TL;DR: It is shown that T-cell Ig and mucin domain 1 (TIM-1) binds to the receptor binding domain of the Zaire Ebola virus (EBOV) glycoprotein, and ectopic TIM-1 expression in poorly permissive cells enhances EBOV infection by 10- to 30-fold.
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Dengue and Zika viruses subvert reticulophagy by NS2B3-mediated cleavage of FAM134B.
TL;DR: It is shown that RNAi-mediated depletion of FAM134B significantly enhances both DENV and ZIKV replication at an early stage of the viral life cycle, suggesting that these viruses specifically target these pathways to promote viral replication.
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Comprehensive Functional Analysis of N-Linked Glycans on Ebola Virus GP1
Nicholas J. Lennemann,Bethany A. Rhein,Esther Ndungo,Kartik Chandran,Xiangguo Qiu,Wendy Maury +5 more
TL;DR: Evidence is provided that filoviruses maintain glycoprotein glycosylation to protect against proteases and antibody neutralization at the expense of efficient entry despite the negative impact the glycans have on viral entry efficiency.
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Filovirus Entry: A Novelty in the Viral Fusion World
TL;DR: This multi-step entry pathway highlights the complex and highly orchestrated path of internalization and fusion that appears unique for filoviruses.