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Yoelvis García-Mesa
Researcher at Case Western Reserve University
Publications - 14
Citations - 1497
Yoelvis García-Mesa is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Physical exercise & Neuroprotection. The author has an hindex of 11, co-authored 11 publications receiving 1237 citations. Previous affiliations of Yoelvis García-Mesa include Spanish National Research Council.
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Journal ArticleDOI
RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection
Wenhui Hu,Rafal Kaminski,Fan Yang,Yonggang Zhang,Laura Cosentino,Fang Li,Biao Luo,David Alvarez-Carbonell,Yoelvis García-Mesa,Jonathan Karn,Xianming Mo,Kamel Khalili +11 more
TL;DR: The results suggest that Cas9/gRNA can be engineered to provide a specific, efficacious prophylactic and therapeutic approach against AIDS.
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Physical exercise protects against Alzheimer's disease in 3xTg-AD mice.
Yoelvis García-Mesa,Juan Carlos López-Ramos,Lydia Giménez-Llort,Susana Revilla,Rafael Guerra,Agnès Gruart,Frank M. LaFerla,Rosa Cristòfol,José M. Delgado-García,Coral Sanfeliu +9 more
TL;DR: The benefits of aerobic physical exercise on synapse, redox homeostasis, and general brain function demonstrated in the 3xTg-AD mouse further support the value of this healthy life-style against neurodegeneration.
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Immortalization of primary microglia: a new platform to study HIV regulation in the central nervous system
Yoelvis García-Mesa,Taylor R. Jay,Mary Ann Checkley,Benjamin Luttge,Curtis Dobrowolski,Saba Valadkhan,Gary E. Landreth,Jonathan Karn,David Alvarez-Carbonell +8 more
TL;DR: The immortalized cells have microglia-like morphology and express key microglial surface markers including CD11b, TGFβR, and P2RY12 and demonstrate the expected migratory and phagocytic activity, and the capacity to mount an inflammatory response characteristic of primarymicroglia.
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Physical exercise improves synaptic dysfunction and recovers the loss of survival factors in 3xTg-AD mouse brain.
Susana Revilla,Cristina Suñol,Yoelvis García-Mesa,Lydia Giménez-Llort,Coral Sanfeliu,Rosa Cristòfol +5 more
TL;DR: The synaptic proteins synaptophysin and PSD-95 and the neuroprotective proteins GDNF and SIRT1 were downregulated in 3xTgAD mice and were recovered by exercise treatment and reduced expression levels of NMDA receptor NR2B subunit were reestablished.
Journal ArticleDOI
Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse.
Yoelvis García-Mesa,Lydia Giménez-Llort,Luis C. López,Carmen Venegas,Rosa Cristòfol,Germain Escames,Darío Acuña-Castroviejo,Coral Sanfeliu +7 more
TL;DR: Interestingly, only the combined treatment of physical exercise plus melatonin was effective against the decrease of mitochondrial complexes, suggesting melatonin plus physical exercise may exert complementary, additive, or even synergistic effects against a range of disturbances present in AD.