J
Jonathan Karn
Researcher at Case Western Reserve University
Publications - 161
Citations - 13789
Jonathan Karn is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: RNA & Transcription (biology). The author has an hindex of 61, co-authored 140 publications receiving 12778 citations. Previous affiliations of Jonathan Karn include Medical Research Council & Beckman Coulter.
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Nucleotide sequence of tobacco mosaic virus RNA
TL;DR: Oligonucleotide primers have been used to generate a cDNA library covering the entire tobacco mosaic virus (TMV) RNA sequence and analysis of these clones has enabled us to complete the viralRNA sequence and to study its variability within a viral population.
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Toward a physical map of the genome of the nematode Caenorhabditis elegans
TL;DR: A technique for digital characterization and comparison of DNA fragments, using restriction enzymes, is described, being applied to fragments from the nematode Caenorhabditis elegans to facilitate cross-indexing of clones emanating from different laboratories and to construct a physical map of the genome.
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RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection
Wenhui Hu,Rafal Kaminski,Fan Yang,Yonggang Zhang,Laura Cosentino,Fang Li,Biao Luo,David Alvarez-Carbonell,Yoelvis García-Mesa,Jonathan Karn,Xianming Mo,Kamel Khalili +11 more
TL;DR: The results suggest that Cas9/gRNA can be engineered to provide a specific, efficacious prophylactic and therapeutic approach against AIDS.
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Human immunodeficiency virus 1 tat protein binds trans-activation-responsive region (TAR) RNA in vitro
Colin Dingwall,Ingemar Ernberg,Michael J. Gait,Sheila M. Green,Shaun Heaphy,Jonathan Karn,Anthony D. Lowe,Mohinder Singh,Michael A. Skinner,Robert Valerio +9 more
TL;DR: Tat, the trans-activator protein for human immunodeficiency virus 1 (HIV-1), has been expressed in Escherichia coli from synthetic genes and binds specifically to HIV-1 trans-activation-responsive region (TAR) RNA in gel-retardation, filter-binding, and immunoprecipitation assays.
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Periodic charge distributions in the myosin rod amino acid sequence match cross-bridge spacings in muscle
A.D. McLachlan,Jonathan Karn +1 more
TL;DR: Calculations suggest that the N-terminal third of the rod is only loosely associated with the thick filament backbone and could be used to act as a hinged arm during muscle contraction.