Sustainable solvents are a topic of growing interest in both the research community and the chemical industry due to a growing awareness of the impact of solvents on pollution, energy usage, and contributions to air quality and climate change. Solvent losses represent a major portion of organic pollution, and solvent removal represents a large proportion of process energy consumption. To counter these issues, a range of greener or more sustainable solvents have been proposed and developed over the past three decades. Much of the focus has been on the environmental credentials of the solvent itself, although how a substance is deployed is as important to sustainability as what it is made from. In this Review, we consider several aspects of the most prominent sustainable organic solvents in use today, ionic liquids, deep eutectic solvents, supercritical fluids, switchable solvents, liquid polymers, and renewable solvents. We examine not only the performance of each class of solvent within the context of the...

Green and Sustainable Solvents in Chemical Processes

Deep eutectic solvents (DESs) are an emerging class of mixtures characterized by significant depressions in melting points compared to those of the neat constituent components. These materials are promising for applications as inexpensive "designer" solvents exhibiting a host of tunable physicochemical properties. A detailed review of the current literature reveals the lack of predictive understanding of the microscopic mechanisms that govern the structure-property relationships in this class of solvents. Complex hydrogen bonding is postulated as the root cause of their melting point depressions and physicochemical properties; to understand these hydrogen bonded networks, it is imperative to study these systems as dynamic entities using both simulations and experiments. This review emphasizes recent research efforts in order to elucidate the next steps needed to develop a fundamental framework needed for a deeper understanding of DESs. It covers recent developments in DES research, frames outstanding scientific questions, and identifies promising research thrusts aligned with the advancement of the field toward predictive models and fundamental understanding of these solvents.

Deep Eutectic Solvents: A Review of Fundamentals and Applications.

https://rua.ua.es/dspace/bitstream/10045/62171/5/2016_Alonso_etal_EurJOC_rev.pdf

Deep Eutectic Solvents: The Organic Reaction Medium of the Century

Deep eutectic solvents (DESs), also known as deep eutectic ionic liquids (DEILs) or low-melting mixtures (LMMs) or low transition temperature mixtures (LTTMs) in the literature, have become more and more attractive in recent years due to their interesting properties and benefits, such as low cost of components, easy to prepare, tunable physicochemical properties, negligible vapor pressure, non-toxicity, biorenewability and biodegradability. These eutectic mixtures have been widely used as green and sustainable media as well as catalysts in many chemical processes. This review focuses on recent advances using DESs in organic reactions including addition reactions, cyclization reactions, replacement reactions, multicomponent reactions, condensation reactions, oxidation reactions, and reducing reactions.

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Recent advances in the application of deep eutectic solvents as sustainable media as well as catalysts in organic reactions

Application of deep eutectic solvents in analytical chemistry. A review

Deep eutectic solvents (DESs) as eco-friendly and sustainable solvent/catalyst systems in organic transformations

An efficient and environmentally benign isocyanide based domino protocol has been presented for the synthesis of structurally diverse spiroheterocycles, spiroannulated with imidazothiazole and imidazothiadiazole, involving the three component reaction of 2-aminobenzothiazole/2-amino-1,3,4-thiadiazole, cyclohexyl/tert-butyl isocyanides and isatines/cyclic carbonyl compounds catalyzed by recyclable and reusable nanocrystalline TiO2

An efficient one pot three-component nanocatalyzed synthesis of spiroheterocycles using TiO2 nanoparticles as a heterogeneous catalyst

An efficient and environmentally sustainable domino protocol has been presented for the synthesis of structurally diverse spiroannulated pyrimidophenazines involving a four component reaction of 2-hydroxynaphthalene-1,4-dione, benzene-1,2-diamine, cyclic ketones and amino derivatives in the presence of erbium doped TiO2 nanoparticles as a recyclable and reusable heterogeneous acid catalyst The present synthetic protocol features mild reaction conditions with operational simplicity, excellent yield with high purity, short reaction time and high atom economy with the use of a recoverable and reusable environmentally sustainable heterogeneous catalyst

/pdf/an-efficient-and-environmentally-sustainable-domino-protocol-3oe8gdrcm2.pdf

An efficient and environmentally sustainable domino protocol for the synthesis of structurally diverse spiroannulated pyrimidophenazines using erbium doped TiO2 nanoparticles as a recyclable and reusable heterogeneous acid catalyst

An efficient and eco-friendly diversity oriented synthetic protocol has been presented to synthesize structurally diverse drug-like small hybrid molecules; indenopyrroloimidazoles, imidazoindoles, chromenopyrroloimidazoles and imidazopyrrlopyrimidines, using deep eutectic solvent (DES), guanidinium chloride and urea, as a sustainable solvent and promoter. The use of DES (guanidinium chloride and urea) as a recyclable and reusable solvent and promoter has been explored for the first time in the synthetic domino protocol involving one-pot, three component reaction of hydantoin, 1,3-diketones and aldehydes with special features of the protocol; high atom-economy, operational simplicity, mild reaction conditions, short reaction time, and high selectivity with excellent yields.

Yogesh Kumar Tailor

Papers

Deep eutectic solvents (DESs) as eco-friendly and sustainable solvent/catalyst systems in organic transformations

An efficient one pot three-component nanocatalyzed synthesis of spiroheterocycles using TiO2 nanoparticles as a heterogeneous catalyst

An efficient and environmentally sustainable domino protocol for the synthesis of structurally diverse spiroannulated pyrimidophenazines using erbium doped TiO2 nanoparticles as a recyclable and reusable heterogeneous acid catalyst

Deep eutectic solvent promoted synthesis of structurally diverse hybrid molecules with privileged heterocyclic substructures

L-Proline Catalyzed Multicomponent Reactions