Y
Yohei Yamauchi
Researcher at University of Bristol
Publications - 70
Citations - 3313
Yohei Yamauchi is an academic researcher from University of Bristol. The author has contributed to research in topics: Virus & Interplanetary scintillation. The author has an hindex of 26, co-authored 62 publications receiving 2154 citations. Previous affiliations of Yohei Yamauchi include Nagoya University & University of Zurich.
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Journal ArticleDOI
Neuropilin-1 is a host factor for SARS-CoV-2 infection.
James L. Daly,Boris Simonetti,Katja Klein,Kai-En Chen,Maia Kavanagh Williamson,Carlos Antón-Plágaro,Deborah K. Shoemark,Lorena Simón-Gracia,Michael Bauer,Reka Hollandi,Urs F. Greber,Peter Horvath,Peter Horvath,Richard B. Sessions,Ari Helenius,Julian A. Hiscox,Julian A. Hiscox,Tambet Teesalu,David A. Matthews,Andrew D. Davidson,Brett M. Collins,Peter J. Cullen,Yohei Yamauchi,Yohei Yamauchi +23 more
TL;DR: It is shown that neuropilin-1 (NRP1), which is known to bind furin-cleaved substrates, potentiates SARS-CoV-2 infectivity and serves as a host factor for Sars-Cov-2 infection and may potentially provide a therapeutic target for COVID-19.
Posted ContentDOI
Neuropilin-1 is a host factor for SARS-CoV-2 infection
James L. Daly,Boris Simonetti,Carlos Antón-Plágaro,Maia Kavanagh Williamson,Deborah K. Shoemark,Lorena Simón-Gracia,Katja Klein,Michael Bauer,Reka Hollandi,Urs F. Greber,Peter Horvath,Richard B. Sessions,Ari Helenius,Julian A. Hiscox,Tambet Teesalu,David A. Matthews,Andrew D. Davidson,Peter J. Cullen,Yohei Yamauchi +18 more
TL;DR: Here it is demonstrated using immunoprecipitation, site-specific mutagenesis, structural modelling, and antibody blockade that S1 can bind to NRP1 through the canonical CendR mechanism, and this interaction enhances infection by SARS-CoV-2 in cell culture.
Journal ArticleDOI
Virus entry at a glance.
Yohei Yamauchi,Ari Helenius +1 more
TL;DR: The goal of a virus particle is to transport its genome in a replication-competent form from an infected cell to an uninfected cell.
Journal ArticleDOI
Influenza A virus uses the aggresome processing machinery for host cell entry.
Indranil Banerjee,Yasuyuki Miyake,Samuel Philip Nobs,Christoph Schneider,Peter Horvath,Manfred Kopf,Patrick Matthias,Patrick Matthias,Ari Helenius,Yohei Yamauchi +9 more
TL;DR: For capsid disassembly, IAV takes advantage of the host cell’s aggresome formation and disassembly machinery, and it is found that physical forces generated by microtubule- and actin-associated motors are essential for IAV entry.
Journal ArticleDOI
Principles of Virus Uncoating: Cues and the Snooker Ball.
Yohei Yamauchi,Urs F. Greber +1 more
TL;DR: How cellular cues, facilitators, and built‐in viral mechanisms promote uncoating are discussed, which will continue to enhance understanding of cell functions, and help counteracting infections with chemicals and vaccines.