Y
Yoichiro Hirata
Researcher at University of Tokyo
Publications - 82
Citations - 2356
Yoichiro Hirata is an academic researcher from University of Tokyo. The author has contributed to research in topics: Inflammation & Adipose tissue. The author has an hindex of 25, co-authored 76 publications receiving 1980 citations. Previous affiliations of Yoichiro Hirata include University of Tokushima.
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Journal ArticleDOI
Coronary Atherosclerosis Is Associated With Macrophage Polarization in Epicardial Adipose Tissue
Yoichiro Hirata,Minoru Tabata,Hirotsugu Kurobe,Tatsuo Motoki,Masashi Akaike,Chika Nishio,Mayuko Higashida,Hiroaki Mikasa,Yutaka Nakaya,Shuichiro Takanashi,Takashi Igarashi,Tetsuya Kitagawa,Masataka Sata +12 more
TL;DR: The ratio of M1/M2 macrophages in epicardial adipose tissue of CAD patients is changed compared with that in non-CAD patients, and human coronary atherosclerosis is associated with macrophage polarization in epicardsial adiposes tissue.
Journal ArticleDOI
Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance
Sachiko Nishimoto,Daiju Fukuda,Yasutomi Higashikuni,Kimie Tanaka,Yoichiro Hirata,Chie Murata,Joo-ri Kim-Kaneyama,Fukiko Sato,Masahiro Bando,Shusuke Yagi,Takeshi Soeki,Tetsuya Hayashi,Issei Imoto,Hiroshi Sakaue,Michio Shimabukuro,Masataka Sata +15 more
TL;DR: It is shown that obesity-related adipocyte degeneration causes release of cell-free DNA (cfDNA), which promotes macrophage accumulation in adipose tissue via Toll-like receptor 9 (TLR9), originally known as a sensor of exogenous DNA fragments, which may provide a novel mechanism for the development of sterile inflammation in adipOSE tissue and a potential therapeutic target for insulin resistance.
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Enhanced inflammation in epicardial fat in patients with coronary artery disease.
Yoichiro Hirata,Hirotsugu Kurobe,Masashi Akaike,Fumio Chikugo,Takaki Hori,Yoshimi Bando,Chika Nishio,Mayuko Higashida,Yutaka Nakaya,Tetsuya Kitagawa,Masataka Sata +10 more
TL;DR: It is suggested that inflammatory cell infiltration is enhanced in epicardial adipose tissue, but not in subcutaneous fat, in patients with coronary artery disease.
Journal ArticleDOI
Epicardial Adipose Tissue Volume and Adipocytokine Imbalance Are Strongly Linked to Human Coronary Atherosclerosis
Michio Shimabukuro,Yoichiro Hirata,Minoru Tabata,Munkhbaatar Dagvasumberel,Hiromi Sato,Hirotsugu Kurobe,Daiju Fukuda,Takeshi Soeki,Tetsuya Kitagawa,Shuichiro Takanashi,Masataka Sata +10 more
TL;DR: EATV and macrophage and cytokine/adipocytokine signals in EAT strongly correlated with CAD and suggest that EATv and adipocytoksine imbalance are strongly linked to human coronary atherosclerosis.
Journal ArticleDOI
Rivaroxaban, a novel oral anticoagulant, attenuates atherosclerotic plaque progression and destabilization in ApoE-deficient mice
Tomoya Hara,Daiju Fukuda,Kimie Tanaka,Yasutomi Higashikuni,Yoichiro Hirata,Sachiko Nishimoto,Shusuke Yagi,Hirotsugu Yamada,Takeshi Soeki,Tetsuzo Wakatsuki,Michio Shimabukuro,Masataka Sata +11 more
TL;DR: The hypothesis that rivaroxaban (Riv), a direct FXa inhibitor, inhibits atherogenesis by reducing macrophage activation is assessed, indicating that Riv may be particularly beneficial for the management of atherosclerotic diseases, in addition to its antithrombotic activity.