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Yong Lin
Researcher at Hunan Agricultural University
Publications - 9
Citations - 144
Yong Lin is an academic researcher from Hunan Agricultural University. The author has contributed to research in topics: Membrane protein & Integral membrane protein. The author has an hindex of 7, co-authored 9 publications receiving 97 citations.
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Anti-melanogenic effects of epigallocatechin-3-gallate (EGCG), epicatechin-3-gallate (ECG) and gallocatechin-3-gallate (GCG) via down-regulation of cAMP/CREB /MITF signaling pathway in B16F10 melanoma cells.
TL;DR: The results revealed catechins could be used as anti-melanogenic agents to protect cells from abnormal melanogenesis and regulated the melanogenesis of B16F10 cells through the cAMP/CREB/MITF pathway.
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Comparative proteomic analysis using 2DE-LC-MS/MS reveals the mechanism of Fuzhuan brick tea extract against hepatic fat accumulation in rats with nonalcoholic fatty liver disease
TL;DR: The reduced lipogenesis and enhanced β‐oxidation, tricarboxylic acid cycle and respiratory chain in HFD + HFTE‐fed rats, which mainly contributed to ameliorate hepatic fat accumulation and associated NAFLD.
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Improvement of a sample preparation method assisted by sodium deoxycholate for mass‐spectrometry‐based shotgun membrane proteomics
TL;DR: The enhanced sodium deoxycholate method exhibited superior sensitivity, coverage, and reliability for the identification of membrane proteins particularly those with high hydrophobicity and/or multiple transmembrane domains.
Journal ArticleDOI
Proteomic analysis of the inhibitory effect of epigallocatechin gallate on lipid accumulation in human HepG2 cells
Zhonghua Liu,Zhonghua Liu,Qin Li,Jianan Huang,Qionglin Liang,Yujun Yan,Haiyan Lin,Wenjun Xiao,Yong Lin,Sheng Zhang,Bin Tan,Guoan Luo +11 more
TL;DR: The proteomic analysis hypothesized that EGCG reduced cellular lipid accumulation in FFA-induced HepG2 cells through the activation of AMP-activated protein kinase (AMPK) resulting from the generation of reactive oxygen species (ROS).
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Enhanced SDC-assisted digestion coupled with lipid chromatography-tandem mass spectrometry for shotgun analysis of membrane proteome.
TL;DR: An enhanced SDC-assisted digestion method was developed that incorporates the almost strongest ability of SDC with a high concentration to lyse membrane and extract/solubilize hydrophobic membrane proteins, and then dilution to 1% for more efficient digestion, demonstrating that the ESDC method provides a substantial improvement in the recovery and identification of membrane proteins.