Yonglong Zou

TL;DR: It is shown that renal fibrosis induced by unilateral ureteral obstruction and metastasis of human cancer xenografts are suppressed by administration of secreted Klotho protein to mice, raising the possibility thatsecreted Kloths may function as an endogenous anti-EMT factor by inhibiting multiple growth factor signaling pathways simultaneously.

TL;DR: Data support the central hypothesis that membrane poration by AmB and increased endosomal swelling and membrane tension by a "proton sponge" polymer provided a synergistic strategy to disrupt endosomes for improved intracellular delivery of siRNA.

TL;DR: Elevated sCLU levels may enhance tumorigenesis by interfering with Bax proapoptotic activities and contribute to one of the major characteristics of cancer cells, that is, resistance to apoptosis.

TL;DR: Clusterin is a key target for developing more effective CRPC therapy and a significantly inverse correlation between DAB2IP and Egr-1 or Clusterin expression from clinical tissue microarray is observed.

TL;DR: Secretory clusterin (sCLU), an extracellular molecular chaperone, induced by low doses of cytotoxic agents, clears cell debris and is a pro-survival bystander factor that abrogates TGFβ1 signaling and most likely promotes wound healing.