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Yongping Yu
Researcher at Zhejiang University
Publications - 205
Citations - 2810
Yongping Yu is an academic researcher from Zhejiang University. The author has contributed to research in topics: Catalysis & Solid-phase synthesis. The author has an hindex of 26, co-authored 193 publications receiving 2497 citations. Previous affiliations of Yongping Yu include Taizhou University & Guangdong Ocean University.
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Journal ArticleDOI
Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods.
Richard A. Houghten,Clemencia Pinilla,Marc A. Giulianotti,Jon R. Appel,Colette T. Dooley,Adel Nefzi,John M. Ostresh,Yongping Yu,Gerald M. Maggiora,José L. Medina-Franco,Daniela Brunner,Jeff Schneider +11 more
TL;DR: The power of synthetic mixture-based combinatorial libraries lies in their ability to accelerate the acquisition of information regarding specific functionalities at each variable position in the library that determines the activity of a specific chemical scaffold or pharmacophore.
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Combinatorial chemistry: libraries from libraries, the art of the diversity-oriented transformation of resin-bound peptides and chiral polyamides to low molecular weight acyclic and heterocyclic compounds.
TL;DR: The authors' efforts over the past 10 years in the design and diversity-oriented synthesis of low molecular weight acyclic and heterocyclic combinatorial libraries derived from amino acids, peptides, and/or peptidomimetics are described.
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Enantioselective synthesis of allylic alcohols by the sequential aminoxylation-olefination reactions of aldehydes under ambient conditions.
Guofu Zhong,Yongping Yu +1 more
TL;DR: A novel, highly enantioselective synthesis of O-amino-substituted allylic alcohols by the sequential asymmetric alpha-aminoxylation/Wadsworth-Emmons-Horner olefination reactions of aldehydes is presented.
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Selective Access to 4-Substituted 2-Aminothiazoles and 4-Substituted 5-Thiocyano-2-aminothiazoles from Vinyl Azides and Potassium Thiocyanate Switched by Palladium and Iron Catalysts.
TL;DR: A highly selective construction of 4-substituted 2-aminothiazoles and 5-thiocyano-2-aminothsiazoles, respectively, catalyzed by palladium(II) acetate and promoted by iron(III) bromide from vinyl azides and potassium thiOCyanate has been developed.
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One-Pot Three-Component Approach to the Synthesis of Polyfunctional Pyrazoles
TL;DR: A simple, multicomponent, and straightforward reaction of vinyl azide, aldehyde, and tosylhydrazine affords the construction of 3,4,5-trisubstituted 1H-pyrazoles regioselectively in the presence of base with moderate to excellent yields.