M
Marc A. Giulianotti
Researcher at Torrey Pines Institute for Molecular Studies
Publications - 107
Citations - 3311
Marc A. Giulianotti is an academic researcher from Torrey Pines Institute for Molecular Studies. The author has contributed to research in topics: Solid-phase synthesis & Receptor. The author has an hindex of 26, co-authored 102 publications receiving 2703 citations. Previous affiliations of Marc A. Giulianotti include Florida International University & Zhejiang University.
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Journal ArticleDOI
The value of antimicrobial peptides in the age of resistance
Maria Magana,Muthuirulan Pushpanathan,Ana L. Santos,Leon G. Leanse,Michael Fernandez,Anastasios Ioannidis,Marc A. Giulianotti,Yiorgos Apidianakis,Steven B. Bradfute,Andrew L. Ferguson,Artem Cherkasov,Mohamed N. Seleem,Clemencia Pinilla,Cesar de la Fuente-Nunez,Themis Lazaridis,Themis Lazaridis,Tianhong Dai,Richard A. Houghten,Robert E. W. Hancock,George P. Tegos +19 more
TL;DR: The benefits, challenges, and opportunities of using antimicrobial peptides against multidrug-resistant pathogens are identified, advances in the deployment of novel promising antimacterial peptides are highlighted, and the needs and priorities in designing focused development strategies taking into account the most advanced tools available are underlined.
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Shifting from the single to the multitarget paradigm in drug discovery.
TL;DR: The concepts of drug repurposing, polypharmacology, chemogenomics, phenotypic screening and high-throughput in vivo testing of mixture-based libraries in an integrated manner are discussed.
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Characterization of activity landscapes using 2D and 3D similarity methods: consensus activity cliffs.
José L. Medina-Franco,Karina Martinez-Mayorga,Andreas Bender,Ray M. Marín,Marc A. Giulianotti,Clemencia Pinilla,Richard A. Houghten +6 more
TL;DR: Results for the current test case suggest that the presence or absence of a methoxybenzyl group may lead to different modes of binding for the active BCGs with the kappa-opioid receptor.
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Chemoinformatic analysis of combinatorial libraries, drugs, natural products, and molecular libraries small molecule repository.
Narender Singh,Rajarshi Guha,Marc A. Giulianotti,Clemencia Pinilla,Richard A. Houghten,José L. Medina-Franco +5 more
TL;DR: A multiple criteria approach is presented, that is used to perform a comparative analysis of four recently developed combinatorial libraries to drugs, Molecular Libraries Small Molecule Repository (MLSMR) and natural products, and fingerprint-based comparisons indicate that these combinatorials are structurally different than current drugs.
Journal ArticleDOI
Visualization of the Chemical Space in Drug Discovery
José L. Medina-Franco,Karina Martinez-Mayorga,Marc A. Giulianotti,Richard A. Houghten,Clemencia Pinilla +4 more
TL;DR: Techniques developed in the group are presented including a quantitative assessment of the multi-fusion similarity maps and an application of 3D-similarity, based on the overlay of chemical structures, to represent the chemical space is introduced.