Yongqiang Zhang

TL;DR: A library of novel evodiamine derivatives bearing various substitutions or modified scaffold were synthesized and showed substantial increase of the antitumor activity, with GI(50) values lower than 3 nM.

TL;DR: The novel pyrrolidone p53-MDM2 inhibitors represent promising lead structures for the development of novel antitumor agents and further hit optimization led to the discovery of a number of highly potent pyrrollidone derivatives with improved p 53- MDM2 inhibitory activity and in vitro antiproliferative potency.

TL;DR: A powerful divergent cascade strategy has been explored for the easy construction of diverse enantioenriched pyrazole-derived scaffolds from readily available chiral fused pyrazoles-tetrahydropyran acetals, revealing potent anticancer lead compounds that deserve further development.

TL;DR: A series of novel antifungal carboline derivatives was designed and synthesized, which showed broad-spectrum antIFungal activity and preliminary mechanism studies revealed that C38 might act by inhibiting the synthesis of fungal cell wall.

TL;DR: Compound 5k showed good antitumor activity and could effectively induce cancer cell apoptosis, which represents a good starting point for the development of novel antitumors agents.