Yoshifumi Tamura

TL;DR: This is the first report of gut dysbiosis in Japanese patients with type 2 diabetes as assessed by RT-qPCR, and the high rate of gut bacteria in the circulation suggests translocation of bacteria from the gut to the bloodstream.

TL;DR: It was found that 2 wk of diet and exercise decreased IMCL and increased muscle insulin-mediated glucose uptake, whereas diet with or without exercise decreased IHL, these effects were evident despite a small decrease in body fat and were observed independently of fasting FFA levels.

TL;DR: It is demonstrated that zinc secreted in concert with insulin suppressed hepatic insulin clearance by inhibiting clathrin-dependent insulin endocytosis and that genetic dysregulation of this system may play a role in the pathogenesis of type 2 diabetes.

TL;DR: GA may be a useful marker for monitoring short-term variations of glycemic control during treatment of diabetic patients, and the percent reduction of HbA1c eventually corresponded with that of GA by 16 weeks after the start of treatment.

TL;DR: Data indicate that prolonged exposure to saturated fat enhances GSIS (but this does not entirely compensate for insulin resistance), whereas unsaturated fat, given in the diet or by infusion, impairs GSIS.