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Yoshikazu Tsuzuki
Researcher at National Defense Medical College
Publications - 94
Citations - 3421
Yoshikazu Tsuzuki is an academic researcher from National Defense Medical College. The author has contributed to research in topics: Intestinal mucosa & Colitis. The author has an hindex of 30, co-authored 85 publications receiving 3245 citations. Previous affiliations of Yoshikazu Tsuzuki include Harvard University & Keio University.
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Journal ArticleDOI
In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy.
Edward B. Brown,Robert B. Campbell,Yoshikazu Tsuzuki,Lei Xu,Peter Carmeliet,Dai Fukumura,Rakesh K. Jain +6 more
TL;DR: It is shown that the multiphoton laser-scanning microscope can provide high three-dimensional resolution of gene expression and function in deeper regions of tumors, which could be critical to the development of novel therapeutics that target not only the tumor surface, but also internal regions.
Journal Article
Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha--> hypoxia response element--> VEGF cascade differentially regulates vascular response and growth rate in tumors.
TL;DR: Host cells are active players in tumor angiogenesis and growth and need to be taken into account in the design of any therapeutic strategy, suggesting a critical role of HRE in tumor cell VEGF production.
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Increased expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in colonic mucosa of patients with active ulcerative colitis
Hiroyuki Kimura,Ryota Hokari,Soichiro Miura,Takeharu Shigematsu,Masahiko Hirokawa,Yasutada Akiba,Iwao Kurose,Hajime Higuchi,Hitoshi Fujimori,Yoshikazu Tsuzuki,Hiroshi Serizawa,Hiromasa Ishii +11 more
TL;DR: Nitric oxide and peroxynitrite formation may play an important role in causing irreversible cellular injury to the colonic mucosa in patients with active ulcerative colitis.
Journal Article
Role of Host Microenvironment in Angiogenesis and Microvascular Functions in Human Breast Cancer Xenografts: Mammary Fat Pad versus Cranial Tumors
Wayne L. Monsky,Carla Mouta Carreira,Yoshikazu Tsuzuki,Takeshi Gohongi,Dai Fukumura,Rakesh K. Jain +5 more
TL;DR: Collectively, host microenvironment is an important determinant of tumor gene expression and microvascular functions, and, thus, orthotopic breast tumor models should be useful for obtaining clinically relevant information.
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Increased nitric oxide production and inducible nitric oxide synthase activity in colonic mucosa of patients with active ulcerative colitis and Crohn's disease.
Hiroyuki Kimura,Soichiro Miura,Takeharu Shigematsu,Nobuyuki Ohkubo,Yoshikazu Tsuzuki,Iwao Kurose,Hajime Higuchi,Yasutada Akiba,Ryota Hokari,Masahiko Hirokawa,Hiroshi Serizawa,Hiromasa Ishii +11 more
TL;DR: Differences in nitric oxide production in the colonic mucosa may reflect the significant differences in the pathophysiology and characteristic clinical features between ulcerative colitis and Crohn's disease.