T
Takeshi Gohongi
Researcher at Harvard University
Publications - 11
Citations - 2895
Takeshi Gohongi is an academic researcher from Harvard University. The author has contributed to research in topics: Angiogenesis & Neovascularization. The author has an hindex of 9, co-authored 11 publications receiving 2751 citations. Previous affiliations of Takeshi Gohongi include University of Tsukuba.
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Journal ArticleDOI
Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability
Dai Fukumura,Takeshi Gohongi,Ananth Kadambi,Yotaro Izumi,Jennifer Ang,Chae-Ok Yun,Donald G. Buerk,Paul L. Huang,Rakesh K. Jain +8 more
TL;DR: It is suggested that eNOS plays a predominant role in VEGF-induced angiogenesis and vascular permeability in vivo, and selective modulation of eN OS activity is a promising strategy for altering angiogenic and vascular porousness in vivo.
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Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors.
Alain Pluen,Yves Boucher,Saroja Ramanujan,Trevor D. McKee,Takeshi Gohongi,Emmanuelle di Tomaso,Edward B. Brown,Yotaro Izumi,Robert B. Campbell,David A. Berk,Rakesh K. Jain +10 more
TL;DR: The results point to the necessity of developing site-specific drug carriers to improve the delivery of molecular medicine to solid tumors.
Journal Article
Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo.
TL;DR: A novel in vivo microscopy technique is developed to show, for the first time, that VEGF transcription in brain tumors is independently regulated by the tissue pO(2) and pH.
Journal Article
Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor.
Wayne L. Monsky,Dai Fukumura,Takeshi Gohongi,Marek Ancukiewcz,Herbert A. Weich,Vladimir P. Torchilin,Fan Yuan,Rakesh K. Jain +7 more
TL;DR: The findings suggest that exogenous VEGF may be useful for augmenting the transvascular delivery of larger antineoplastic agents such as gene targeting vectors and encapsulated drug carriers into tumors.
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NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels.
Satoshi Kashiwagi,Yotaro Izumi,Takeshi Gohongi,Zoe N. Demou,Lei Xu,Paul L. Huang,Donald G. Buerk,Lance L. Munn,Rakesh K. Jain,Dai Fukumura +9 more
TL;DR: It is found that NO mediates mural cell coverage as well as vessel branching and longitudinal extension but not the circumferential growth of blood vessels in B16 murine melanomas.