Y
Yoshimasa Oyama
Researcher at University of Colorado Denver
Publications - 23
Citations - 230
Yoshimasa Oyama is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: PER2 & Hypoxia-inducible factors. The author has an hindex of 8, co-authored 23 publications receiving 164 citations. Previous affiliations of Yoshimasa Oyama include Anschutz Medical Campus & Oita University.
Papers
More filters
Journal ArticleDOI
Intense light-elicited upregulation of miR-21 facilitates glycolysis and cardioprotection through Per2-dependent mechanisms.
Colleen Marie Bartman,Yoshimasa Oyama,Yoshimasa Oyama,Kelley S. Brodsky,Ludmila Khailova,Lori A. Walker,Michael Koeppen,Tobias Eckle +7 more
TL;DR: MiR-21 is identified as cardioprotective downstream target of Per2 and intense light therapy is suggested as a potential strategy to enhance miR- 21 activity and subsequent carbohydrate metabolism in humans.
Journal ArticleDOI
Circadian MicroRNAs in Cardioprotection.
TL;DR: This review will focus on circadian microRNAs in the context of cardioprotection and will highlight new discoveries, which could lead to novel therapeutic concepts to treat myocardial ischemia.
Journal ArticleDOI
Intense Light-Mediated Circadian Cardioprotection via Transcriptional Reprogramming of the Endothelium
Yoshimasa Oyama,Colleen M. Bartman,Stephanie Bonney,J. Scott Lee,Lori A. Walker,Jun Han,Christoph H. Borchers,Christoph H. Borchers,Peter M. Buttrick,Carol M. Aherne,Nathan Clendenen,Sean P. Colgan,Tobias Eckle +12 more
TL;DR: It is demonstrated that intense light is cardioprotective via circadian PER2 amplitude enhancement, mimicking hypoxia-elicited adenosine- and HIF1A-metabolic adaptation to myocardial ischemia under normoxic conditions.
Journal ArticleDOI
The Circadian PER2 Enhancer Nobiletin Reverses the Deleterious Effects of Midazolam in Myocardial Ischemia and Reperfusion Injury.
TL;DR: Findings highlight PER2 as a cardioprotective mechanism and suggest the PER2 enhancers nobiletin or tangeritin as a preventative therapy for myocardial IR-injury in the perioperative setting where midazolam pretreatment occurs frequently.
Journal ArticleDOI
Uncoupling of peripheral and master clock gene rhythms by reversed feeding leads to an exacerbated inflammatory response after polymicrobial sepsis in mice.
Yoshimasa Oyama,Hideo Iwasaka,Hironori Koga,Chihiro Shingu,Shigekiyo Matsumoto,Takayuki Noguchi +5 more
TL;DR: It is suggested that uncoupling of peripheral and master clock gene rhythms by reversed feeding exacerbates inflammatory responses and may also increase the levels of inflammatory cytokines, thereby increasing mortality in a mouse sepsis model.