Y
Yoshimichi Okayama
Researcher at Nihon University
Publications - 140
Citations - 7022
Yoshimichi Okayama is an academic researcher from Nihon University. The author has contributed to research in topics: Mast cell & Immunoglobulin E. The author has an hindex of 44, co-authored 139 publications receiving 6497 citations. Previous affiliations of Yoshimichi Okayama include Southampton General Hospital & National Institutes of Health.
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Journal ArticleDOI
Interleukin 4 is localized to and released by human mast cells
Peter Bradding,I. Feather,Peter H. Howarth,R Mueller,J A Roberts,KM Britten,J P Bews,T C Hunt,Yoshimichi Okayama,C H Heusser +9 more
TL;DR: It is proposed that mast cell activation in an allergic response provides a rapid and local pulse of IL-4 into the local environment essential for the triggering of T lymphocytes into sustainedIL-4 production and to initiate inflammatory cell accumulation and activation.
Journal ArticleDOI
Development, migration, and survival of mast cells.
TL;DR: The factors that regulate mast cell development, migration, and survival are discussed including cytokines that are secreted from activated T cells and other immune cells including mast cells themselves.
Journal ArticleDOI
IL-33 can promote survival, adhesion and cytokine production in human mast cells.
Motoyasu Iikura,Hajime Suto,Hajime Suto,Naoki Kajiwara,Keisuke Oboki,Tatsukuni Ohno,Yoshimichi Okayama,Hirohisa Saito,Stephen J. Galli,Susumu Nakae,Susumu Nakae +10 more
TL;DR: The hypothesis that IL-33 may enhance mast cell function in allergic disorders and other settings, either in the presence or absence of co-stimulation of mast cells via IgE/antigen–FcɛRI signals is supported.
Journal Article
Heterogeneity of human mast cells based on cytokine content.
TL;DR: The results indicate that in addition to exhibiting heterogeneity with respect to neutral protease content of the secretory granules, human mast cells are also heterogeneous withrespect to cytokine content.
Journal ArticleDOI
IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcεRI signals
Lien H. Ho,Tatsukuni Ohno,Keisuke Oboki,Naoki Kajiwara,Hajime Suto,Hajime Suto,Motoyasu Iikura,Yoshimichi Okayama,Shizuo Akira,Hirohisa Saito,Stephen J. Galli,Susumu Nakae +11 more
TL;DR: It is found that IL‐33, but not IL‐1β or IL‐18, induced IL‐13 and IL‐6 production by mouse bone marrow‐derived, cultured mast cells (BMCMCs) independently of IgE, and potential roles for IL‐ 33 in mast cell‐ and Th2 cytokine‐associated immune responses and disorders are suggested.