M
Motoyasu Iikura
Researcher at Stanford University
Publications - 6
Citations - 1431
Motoyasu Iikura is an academic researcher from Stanford University. The author has contributed to research in topics: Immunoglobulin E & Mast cell. The author has an hindex of 6, co-authored 6 publications receiving 1366 citations.
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Journal ArticleDOI
Mast Cells Enhance T Cell Activation: Importance of Mast Cell Costimulatory Molecules and Secreted TNF
Susumu Nakae,Hajime Suto,Hajime Suto,Motoyasu Iikura,Maki Kakurai,Jonathon D. Sedgwick,Mindy Tsai,Stephen J. Galli +7 more
TL;DR: It is found that the secretion of soluble TNF and direct cell-cell interactions between mast cell OX40L and T cell Ox40 contribute to the ability of IgE- and Ag-stimulated mouse mast cells to enhance T cell activation.
Journal ArticleDOI
IL-33 can promote survival, adhesion and cytokine production in human mast cells.
Motoyasu Iikura,Hajime Suto,Hajime Suto,Naoki Kajiwara,Keisuke Oboki,Tatsukuni Ohno,Yoshimichi Okayama,Hirohisa Saito,Stephen J. Galli,Susumu Nakae,Susumu Nakae +10 more
TL;DR: The hypothesis that IL-33 may enhance mast cell function in allergic disorders and other settings, either in the presence or absence of co-stimulation of mast cells via IgE/antigen–FcɛRI signals is supported.
Journal ArticleDOI
IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcεRI signals
Lien H. Ho,Tatsukuni Ohno,Keisuke Oboki,Naoki Kajiwara,Hajime Suto,Hajime Suto,Motoyasu Iikura,Yoshimichi Okayama,Shizuo Akira,Hirohisa Saito,Stephen J. Galli,Susumu Nakae +11 more
TL;DR: It is found that IL‐33, but not IL‐1β or IL‐18, induced IL‐13 and IL‐6 production by mouse bone marrow‐derived, cultured mast cells (BMCMCs) independently of IgE, and potential roles for IL‐ 33 in mast cell‐ and Th2 cytokine‐associated immune responses and disorders are suggested.
Journal ArticleDOI
Mast cell-derived TNF contributes to airway hyperreactivity, inflammation, and TH2 cytokine production in an asthma model in mice.
Susumu Nakae,Lien H. Ho,Mang Yu,Rossella Monteforte,Motoyasu Iikura,Hajime Suto,Hajime Suto,Stephen J. Galli +7 more
TL;DR: The hypothesis that mast cell-derived TNF can promote allergic inflammation and AHR in asthma is supported by the findings in mice.
Journal ArticleDOI
TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells.
Susumu Nakae,Susumu Nakae,Motoyasu Iikura,Hajime Suto,Hajime Suto,Hisaya Akiba,Dale T. Umetsu,Rosemarie H. DeKruyff,Hirohisa Saito,Stephen J. Galli +9 more
TL;DR: It is found that TIM-1 and TIM-3, but neither TIM-2 nor TIM-4, were constitutively expressed on mouse peritoneal mast cells and bone marrow-derived cultured mast cells (BMCMCs).