Yoshinori Okamoto

TL;DR: It is found that PRDM14, the PR domain-containing transcriptional regulator, accelerates the TET-BER cycle, resulting in the promotion of active DNA demethylation in ESCs, and mechanistic insight into DNA dem methylation in naive pluripotent stem cells and developing PGCs is provided.

TL;DR: A quinuclidine derivative represented by general formula (I), a salt, N-oxide or quaternary ammonium salt thereof, and a medicinal composition containing the same, wherein the ring A represents optionally substituted aryl, cycloalkyl, cycloenyl, heteroaryl containing 1 to 4 heteroatoms selected from among oxygen, nitrogen and sulfur, or 5- to 7-membered saturated heterocycle; X represents a single bond or methylene; R represents halogeno, hydroxy, lower alkoxy, carboxy, lower carb

TL;DR: Oral treatment with daidzein or equol at a human equivalent dose suppressed the growth of both DMBA-induced mammary tumors and human MCF-7 breast cancer xenografts in rodents, the inhibitory activity being superior to that of genistein or tamoxifen.

TL;DR: Compound 27c is the first example that shows a strong inhibitory activity without the carboxyl group at the P1 position, and dose dependently inhibited LPS-primed ATP-induced IL-1 beta release in mice.

TL;DR: The results suggest that Cu(I) and H2O2 produced via oxidation of ethylhydroquinone and 4-ethylcatechol are involved in oxidative DNA damage, which would be involved in the mechanism of carcinogenesis by ethylbenzene.