S
Shinya Shibutani
Researcher at Stony Brook University
Publications - 108
Citations - 7845
Shinya Shibutani is an academic researcher from Stony Brook University. The author has contributed to research in topics: DNA & DNA polymerase. The author has an hindex of 40, co-authored 108 publications receiving 7604 citations. Previous affiliations of Shinya Shibutani include State University of New York System.
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Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG.
TL;DR: DCMP and dAMP are incorporated selectively opposite 8-oxodG with transient inhibition of chain extension occurring 3' to the modified base, and the potentially mutagenic insertion of dAMP is targeted exclusively to the site of the lesion.
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8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity.
Julia Tchou,H. Kasai,Shinya Shibutani,Myung-Hee Chung,J. Laval,Arthur P. Grollman,Susumu Nishimura +6 more
TL;DR: 8-oxodG DNA is the primary physiological substrate for a constituent glycosylase found in bacteria and mammalian cells, and it is proposed that the existence of a bacterial gene coding for FPG protein is proposed.
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Aristolochic acid and the etiology of endemic (Balkan) nephropathy
Arthur P. Grollman,Shinya Shibutani,Masaaki Moriya,Frederick W. Miller,Lin Wu,Ute M. Moll,Naomi Suzuki,Andrea Fernandes,Thomas A. Rosenquist,Zvonimir Medverec,Krunoslav Jakovina,Branko Brdar,Neda Slade,Robert J. Turesky,Goodenough Angela,Robert Rieger,Mato Vukelić,Bojan Jelaković +17 more
TL;DR: The experiments test the hypothesis that chronic dietary poisoning by aristolochic acid is responsible for EN and its associated urothelial cancer and conclude that dietary exposure to AA is a significant risk factor for ENand its attendant transitional cell cancer.
Journal ArticleDOI
Substrate specificity of Fpg protein. Recognition and cleavage of oxidatively damaged DNA.
Julia Tchou,V. Bodepudi,Shinya Shibutani,I Antoshechkin,J Miller,Arthur P. Grollman,Francis Johnson +6 more
TL;DR: Data suggest that the C8 keto group of 8-oxodeoxyguanine and the carbonyl moiety of formamidopyrimidine enable Fpg protein to recognize and bind duplex DNA containing these modified bases.
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NMR structural studies of the ionizing radiation adduct 7-hydro-8-oxodeoxyguanosine (8-oxo-7H-dG) opposite deoxyadenosine in a DNA duplex. 8-Oxo-7H-dG(syn).cntdot.dA(anti) alignment at lesion site
Michael Kouchakdjian,Veeraiah Bodepudi,Shinya Shibutani,Moises Eisenberg,Francis Johnson,Arthur P. Grollman,Dinshaw J. Patel +6 more
TL;DR: The present study focuses on the major component of the equilibrium that originates in the 6,8-dioxo tautomer of 8-oxo-7H-dG, which contains a centrally located 7-hydro-8-oxodeoxyguanosine residue, a group commonly found in DNA that has been exposed to ionizing radiation or oxidizing free radicals.