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You-Tang Shen
Researcher at University of Medicine and Dentistry of New Jersey
Publications - 62
Citations - 3289
You-Tang Shen is an academic researcher from University of Medicine and Dentistry of New Jersey. The author has contributed to research in topics: Hemodynamics & Blood flow. The author has an hindex of 27, co-authored 62 publications receiving 3186 citations. Previous affiliations of You-Tang Shen include Harvard University & Pennsylvania State University.
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Journal ArticleDOI
Recombinant Glucagon-Like Peptide-1 Increases Myocardial Glucose Uptake and Improves Left Ventricular Performance in Conscious Dogs With Pacing-Induced Dilated Cardiomyopathy
Lazaros A. Nikolaidis,Dariush Elahi,Teresa Hentosz,Aaron Doverspike,Rhonda Huerbin,Lee Zourelias,Carol Stolarski,You-Tang Shen,Richard P. Shannon +8 more
TL;DR: rGLP-1 dramatically improved LV and systemic hemodynamics in conscious dogs with advanced DCM induced by rapid pacing and may be a useful metabolic adjuvant in decompensated heart failure.
Journal ArticleDOI
Direct Effects of Glucagon-Like Peptide-1 on Myocardial Contractility and Glucose Uptake in Normal and Postischemic Isolated Rat Hearts
Tingcun Zhao,Pratik Parikh,Siva Bhashyam,Hakki Bolukoglu,Indu G. Poornima,You-Tang Shen,Richard P. Shannon +6 more
TL;DR: GLP-1 has direct effects on the normal heart, reducing contractility, but increasing myocardial glucose uptake through a non-Akt-1-dependent mechanism, distinct from the actions of insulin.
Journal ArticleDOI
Active metabolite of GLP-1 mediates myocardial glucose uptake and improves left ventricular performance in conscious dogs with dilated cardiomyopathy
TL;DR: In DCM, GLP-1-(9-36) mimics the effects ofGLP- 1-36 in stimulating myocardial glucose uptake and improving left ventricular (LV) and systemic hemodynamics through insulinomimetic as opposed to insulinotropic effects.
Journal ArticleDOI
Mechanism of Impaired Myocardial Function During Progressive Coronary Stenosis in Conscious Pigs Hibernation Versus Stunning
You-Tang Shen,Stephen F. Vatner +1 more
TL;DR: The data suggest that the reduced function during ameroid-induced coronary stenosis reflected cumulative myocardial stunning rather than a primary deficit in coronary blood flow or "hibernating myocardium."
Journal ArticleDOI
Peripheral Vascular Endothelial Dysfunction and Apoptosis in Old Monkeys
Kuniya Asai,Raymond K. Kudej,You-Tang Shen,Gui Ping Yang,Gen Takagi,Amelia B. Kudej,Yong Jian Geng,Naoki Sato,Jerome B. Nazareno,Dorothy E. Vatner,Filipinas F. Natividad,Sanford P. Bishop,Stephen F. Vatner +12 more
TL;DR: Vascular endothelial dysfunction was present in old monkeys without evidence of atherosclerosis, which may be due to endothelial apoptosis and reduced endothelial cell density.