Y
Young-Hyun You
Researcher at City of Hope National Medical Center
Publications - 4
Citations - 999
Young-Hyun You is an academic researcher from City of Hope National Medical Center. The author has contributed to research in topics: Pyrimidine dimer & 5-Methylcytosine. The author has an hindex of 4, co-authored 4 publications receiving 919 citations.
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Mutations induced by ultraviolet light
TL;DR: It is shown that CPDs (rather than 6-4 photoproducts or other lesions) are responsible for the great majority of UVB-induced mutations and the role of DNA damage-tolerant DNA polymerases in UV lesion bypass and mutagenesis is discussed.
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Cyclobutane pyrimidine dimers form preferentially at the major p53 mutational hotspot in UVB-induced mouse skin tumors.
TL;DR: The data suggest that formation of CPDs is responsible for induction of the major p53 mutational hotspot in UV-induced mouse skin tumors.
Journal ArticleDOI
Similarities in sunlight-induced mutational spectra of CpG-methylated transgenes and the p53 gene in skin cancer point to an important role of 5-methylcytosine residues in solar UV mutagenesis
Young-Hyun You,Gerd P. Pfeifer +1 more
TL;DR: The combined data make a strong case that cyclobutane pyrimidine dimers forming preferentially at dipyrimidine sequences with 5-methylcytosine are responsible for a considerable fraction of the mutations induced by sunlight in mammalian cells.
Journal ArticleDOI
Involvement of 5-methylcytosine in sunlight-induced mutagenesis.
TL;DR: The data indicate that dipyrimidines that contain 5-methylcytosine are preferential targets for sunlight-induced mutagenesis in cultured mammalian cells, thus explaining the large proportion of p53 mutations at such sites in skin tumors in vivo.