Y
Young-Jun Park
Researcher at Seoul National University
Publications - 135
Citations - 2119
Young-Jun Park is an academic researcher from Seoul National University. The author has contributed to research in topics: Engineering & Computer science. The author has an hindex of 22, co-authored 117 publications receiving 1635 citations. Previous affiliations of Young-Jun Park include Jeju National University.
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Future prospects of immune checkpoint blockade in cancer: from response prediction to overcoming resistance
TL;DR: It is reported that combining two ICBs can improve efficacy, and new pre-, and post-treatment tests to determine whether a drug will work for a particular patient are discussed, and manipulating patients’ intestinal microflora can improve response to ICBs.
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p53 Attenuates Lipopolysaccharide-Induced NF-κB Activation and Acute Lung Injury
TL;DR: It is found that neutrophils and macrophages lacking p53 have elevated responses to LPS stimulation compared with p53+/+ cells, producing greater amounts of proinflammatory cytokines, and demonstrating enhanced NF-κB DNA-binding activity.
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Participation of mammalian target of rapamycin complex 1 in Toll-like receptor 2- and 4-induced neutrophil activation and acute lung injury.
Emmanuel Lorne,Xia Zhao,Jaroslaw W. Zmijewski,Gang Liu,Young-Jun Park,Yuko Tsuruta,Edward Abraham +6 more
TL;DR: Results indicate that mTORC1 activation is essential in TLR2- and TLR4-induced neutrophil activation, as well as in the development and severity of acute lung injury.
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Conversion of Th2 memory cells into Foxp3+ regulatory T cells suppressing Th2-mediated allergic asthma.
Byung Seok Kim,Il-Kyu Kim,Young-Jun Park,Yun Sun Kim,Yeon-Jeong Kim,Woo Sung Chang,Yoon-Sook Lee,Mi-Na Kweon,Yeonseok Chung,Chang-Yuil Kang +9 more
TL;DR: The findings reveal the plasticity of Th2 memory cells and provide a strategy for adoptive immunotherapy for the treatment of allergic diseases.
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Role of extracellular superoxide in neutrophil activation: interactions between xanthine oxidase and TLR4 induce proinflammatory cytokine production.
Emmanuel Lorne,Jaroslaw W. Zmijewski,Xia Zhao,Gang Liu,Yuko Tsuruta,Young-Jun Park,Hervé Dupont,Edward Abraham +7 more
TL;DR: It is demonstrated that extracellular superoxide has proinflammatory effects on neutrophils, predominantly acting through an TLR4-dependent mechanism that enhances nuclear translocation ofNF-kappaB and increases expression of NF- kappaB-dependent cytokines.