Young-Kwon Hong

TL;DR: Data identify T1α/podoplanin as a novel critical player that regulates different key aspects of lymphatic vasculature formation as well as small interfering RNA‐mediated inhibition of T1 α/Podoplanin expression decreased lymphatic endothelial cell adhesion.

TL;DR: Although podoplanin was primarily absent from normal human epidermis, its expression was strongly induced in 22 of 28 squamous cell carcinomas studied, and this work identifies the first commercially available antibody for the specific staining of a defined lymphatic marker in archival human tissue sections, thereby enabling more widespread studies of tumor lymphangiogenesis in human cancers.

TL;DR: It is confirmed that Prox1 is a key player in the molecular pathway leading to the formation of lymphatic vasculature and identified as a master switch in the program specifying lymphatic endothelial cell fate, and that a single gene product was sufficient to re‐program the blood vascular endothelium toward a lymphatic phenotype.

TL;DR: It is demonstrated that some lineage-specific genes are only expressed during distinct developmental stages and new molecular markers for blood vascular and lymphatic endothelium are identified with important implications for future studies of vascular development and function.

TL;DR: Findings indicate that overexpression of IL‐8 promotes tumor growth, metastasis, chemoresistance and angiogenesis, implyingIL‐8 to be an important therapeutic target in CRC.