R
Robert D. Ladner
Researcher at University of Southern California
Publications - 59
Citations - 3731
Robert D. Ladner is an academic researcher from University of Southern California. The author has contributed to research in topics: Thymidylate synthase & Colorectal cancer. The author has an hindex of 32, co-authored 59 publications receiving 3458 citations. Previous affiliations of Robert D. Ladner include National Institutes of Health & University of Medicine and Dentistry of New Jersey.
Papers
More filters
Journal ArticleDOI
Interleukin‐8 is associated with proliferation, migration, angiogenesis and chemosensitivity in vitro and in vivo in colon cancer cell line models
Yan Ning,Philipp C. Manegold,Young-Kwon Hong,Wu Zhang,A. Pohl,Georg Lurje,Thomas Winder,Dongyun Yang,Melissa J. LaBonte,Peter M. Wilson,Robert D. Ladner,Heinz-Josef Lenz +11 more
TL;DR: Findings indicate that overexpression of IL‐8 promotes tumor growth, metastasis, chemoresistance and angiogenesis, implyingIL‐8 to be an important therapeutic target in CRC.
Journal Article
A novel single nucleotide polymorphism within the 5' tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity.
Michael V Mandola,Jan Stoehlmacher,Susan Muller-Weeks,Gregory Cesarone,Mimi C. Yu,Heinz-Josef Lenz,Robert D. Ladner +6 more
TL;DR: A novel G-->C single nucleotide polymorphism in the second repeat of 3R alleles within the USF consensus element that alters the ability of USF proteins to bind and thus alters the transcriptional activation of TS gene constructs bearing this genotype is identified.
Journal ArticleDOI
Standing the test of time: targeting thymidylate biosynthesis in cancer therapy
TL;DR: The pivotal discoveries that led to the rational development of thymidylate biosynthesis as a chemotherapeutic target are overviewed, and the crucial contribution of these advances to driving and accelerating drug development in the earliest era of cancer chemotherapy is highlighted.
Journal ArticleDOI
A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels.
Michael V Mandola,Jan Stoehlmacher,Wu Zhang,Susan Groshen,Mimi C. Yu,Syma Iqbal,Heinz-Josef Lenz,Robert D. Ladner +7 more
TL;DR: The results suggest that the 6 bp/1494 polymorphism in the 3'UTR of TS is associated with decreased mRNA stability in vitro and lower intratumoral TS expression in vivo, and may be a useful screening tool in predicting TS mRNA expression.
Journal ArticleDOI
Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis.
Yong Suk Lee,Inho Choi,Yan Ning,Nam Yoon Kim,V Khatchadourian,D. Y. Yang,Hee Kyoung Chung,Dongwon Choi,Melissa J. LaBonte,Robert D. Ladner,K C Nagulapalli Venkata,D O Rosenberg,Nicos A. Petasis,H-J. Lenz,Y-K Hong +14 more
TL;DR: This study demonstrates the critical roles of the tumour microenvironment-encoded IL-8/CXCR2 in colon cancer pathogenesis, validating the pathway as an important therapeutic target.