Y
Young-Mi Go
Researcher at Emory University
Publications - 145
Citations - 8304
Young-Mi Go is an academic researcher from Emory University. The author has contributed to research in topics: Oxidative stress & Thioredoxin. The author has an hindex of 43, co-authored 122 publications receiving 7249 citations. Previous affiliations of Young-Mi Go include University of Alabama at Birmingham.
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Journal ArticleDOI
Redox compartmentalization in eukaryotic cells.
Young-Mi Go,Dean P. Jones +1 more
TL;DR: In this paper, the redox control networks of eukaryotic cells have been investigated and further elucidation of these networks within compartments will improve the mechanistic understanding of cell functions and their disruption in disease.
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Nonequilibrium thermodynamics of thiol/disulfide redox systems: a perspective on redox systems biology.
TL;DR: Thiol/disulfide pathway, redox potential, and rate information are summarized as a basis for kinetic modeling of sulfur switches and indicates that systems biology could encourage novel therapeutic approaches to protect against oxidative stress by identifying specific redox-sensitive sites which could be targeted for intervention.
Journal ArticleDOI
Nuclear and mitochondrial compartmentation of oxidative stress and redox signaling
TL;DR: New methods to measure thiol oxidation show that redox compartmentation functions as a mechanism for specificity in redox signaling and oxidative stress and will provide improved understanding of the pharmacologic and toxicologic actions of drugs and toxicants.
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Cysteine/cystine redox signaling in cardiovascular disease
Young-Mi Go,Dean P. Jones +1 more
TL;DR: The critical nature of the proinflammatory redox signaling and cell biology associated with E(h)CySS supports the use of plasma levels of Cys, CySS, and E( h)Cy SS as key indicators of vascular health.
Journal ArticleDOI
Cysteine/cystine couple is a newly recognized node in the circuitry for biologic redox signaling and control
Dean P. Jones,Young-Mi Go,Corinna L. Anderson,Thomas R. Ziegler,Joseph M. Kinkade,W G Kirlin +5 more
TL;DR: The present study shows that the steady‐state redox potential of the cysteine/cystine couple in cells is sufficiently oxidized relative to the GSH/GSSG and thioredoxin redox couples for the cystine/ Cysteine couple to function as an oxidant in redox switching.