Y
Yu Luo
Researcher at East China Normal University
Publications - 52
Citations - 699
Yu Luo is an academic researcher from East China Normal University. The author has contributed to research in topics: Camptothecin & Ethylene glycol. The author has an hindex of 14, co-authored 52 publications receiving 620 citations.
Papers
More filters
Journal ArticleDOI
Synthesis and anti-hepatitis B virus activity of novel benzimidazole derivatives.
Yun Fei Li,Gui Feng Wang,Pei Lan He,Weigang Huang,Feng Hua Zhu,He Yong Gao,Wei Tang,Yu Luo,Chun Lan Feng,Li Ping Shi,Yu Dan Ren,Wei Lu,Jian Ping Zuo +12 more
TL;DR: A series of novel benzimidazole derivatives was synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in vitro and the most promising compounds were 12a and 12b, with similar high antiviral potency and remarkable selectivity indices.
Journal ArticleDOI
Total Synthesis of Camptothecin and SN-38
TL;DR: The development of column chromatography-free purification was achieved in all steps, which offers an economic industrial process to the camptothecin-family alkaloids.
Journal ArticleDOI
The discovery of colchicine-SAHA hybrids as a new class of antitumor agents.
TL;DR: A novel class of colchicine-SAHA hybrids were designed and synthesised based on the synergistic antitumor effect of tubulin inhibitors and histone deacetylases (HDAC) inhibitors, which is the first design of molecules that are dual inhibitors of Tubulin and HDAC.
Journal ArticleDOI
Design and synthesis of novel benzimidazole derivatives as inhibitors of hepatitis B virus.
TL;DR: A series of novel benzimidazole derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in the HepG2.2.15 cell line and compound 12a was the most promising compound and selected as the benchmark compound for further optimization.
Journal ArticleDOI
Fabrication of biodegradable micelles with sheddable poly(ethylene glycol) shells as the carrier of 7-ethyl-10-hydroxy-camptothecin
TL;DR: Water-insoluble antitumor drug, SN-38, was easily encapsulated into mPEG-SS-PBLG nanomicelles by lyophilization method, suggesting their passive targeting potential to tumor tissue.