Yu Xia

TL;DR: Primary structure predictions indicate that the NAC peptide sequence has a strong tendency to form beta-structures consistent with its association with amyloid, and the availability of the cDNA encoding full-length NACP should help to elucidate the mechanisms of amyloidsosis in AD.

TL;DR: It is suggested that NACP/alpha-synuclein aggregation might be closely related to oxidative reactions which may play a critical role in neurodegeneration in disorders with Lewy bodies.

TL;DR: A dinucleotide repeat polymorphism in a tau intron was identified and used in a case-control study to analyze the genetic association of tau with several neurodegenerative diseases with tau pathology as discussed by the authors.

TL;DR: Using a biallelic genetic marker in exon 3 LRP, late-onset AD cases markedly differed from the control subjects in the distribution of LRP genotypes, and this difference was highly accentuated among AD cases with positive family history of senile dementia.

TL;DR: This work has shown that in vitro aggregates of NACP/alpha-synuclein form Thioflavine-S-positive filamentous structures, reminiscent of amyloid-like fibrils, which could play a crucial role in pathogenesis of disorders with Lewy bodies such as Parkinson's disease.