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Yu Xia
Researcher at University of California, San Diego
Publications - 22
Citations - 3925
Yu Xia is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Lewy body & Alzheimer's disease. The author has an hindex of 17, co-authored 17 publications receiving 3769 citations.
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Journal ArticleDOI
Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease
Kenji Uéda,Hisashi Fukushima,Eliezer Masliah,Yu Xia,Akihiko Iwai,Makoto Yoshimoto,Deborah A. C. Otero,Jun Kondo,Yasuo Ihara,Tsunao Saitoh +9 more
TL;DR: Primary structure predictions indicate that the NAC peptide sequence has a strong tendency to form beta-structures consistent with its association with amyloid, and the availability of the cDNA encoding full-length NACP should help to elucidate the mechanisms of amyloidsosis in AD.
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Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro.
TL;DR: It is suggested that NACP/alpha-synuclein aggregation might be closely related to oxidative reactions which may play a critical role in neurodegeneration in disorders with Lewy bodies.
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Genetic evidence for the involvement of τ in progressive supranuclear palsy
Chris Conrad,Athena Andreadis,John Q. Trojanowski,Dennis W. Dickson,David E. Kang,Xiaohua Chen,W. C. Wiederholt,L. A. Hansen,Eliezer Masliah,Leon J. Thal,Robert Katzman,Yu Xia,Tsunao Saitoh +12 more
TL;DR: A dinucleotide repeat polymorphism in a tau intron was identified and used in a case-control study to analyze the genetic association of tau with several neurodegenerative diseases with tau pathology as discussed by the authors.
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Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease
David E. Kang,Tsunao Saitoh,Xu Chen,Yu Xia,Eliezer Masliah,L. A. Hansen,R. G. Thomas,Leon J. Thal,Robert Katzman +8 more
TL;DR: Using a biallelic genetic marker in exon 3 LRP, late-onset AD cases markedly differed from the control subjects in the distribution of LRP genotypes, and this difference was highly accentuated among AD cases with positive family history of senile dementia.
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Human recombinant NACP/α-synuclein is aggregated and fibrillated in vitro: Relevance for Lewy body disease
Makoto Hashimoto,Leigh J. Hsu,Abbyanne Sisk,Yu Xia,Ayako Takeda,Ayako Takeda,Mary Sundsmo,Eliezer Masliah +7 more
TL;DR: This work has shown that in vitro aggregates of NACP/alpha-synuclein form Thioflavine-S-positive filamentous structures, reminiscent of amyloid-like fibrils, which could play a crucial role in pathogenesis of disorders with Lewy bodies such as Parkinson's disease.