Y
Yuan-Chih Chang
Researcher at Academia Sinica
Publications - 62
Citations - 1712
Yuan-Chih Chang is an academic researcher from Academia Sinica. The author has contributed to research in topics: Carbon nanotube & Homologous recombination. The author has an hindex of 17, co-authored 60 publications receiving 1230 citations. Previous affiliations of Yuan-Chih Chang include National Yunlin University of Science and Technology.
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Journal ArticleDOI
Hollow Cone Electron Imaging for Single Particle 3D Reconstruction of Proteins
TL;DR: Hollow cone dark field imaging using thermal diffuse scattered electrons gives about a 4 times contrast increase as compared to bright field imaging, and demonstrates the 3D reconstruction of a stained GroEL particle can yield about 13.5 Å resolution but using a strongly reduced number of images.
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Polymerization of a Confined π-System: Chemical Synthesis of Tetrahedral Amorphous Carbon Nanoballs from Graphitic Carbon Nanocapsules
Cheng-Che Chu,Gan-Lin Hwang,Jau-Wern Chiou,Way-Faung Pong,Cheng-Lan Lin,Chien-Ying Tsai,Hsiu-Mei Lin,Yuan-Chih Chang,Chia-Seng Chang,Allen Hsu,Wuu-Liang Huang,Jinghua Guo,Ping-Hei Chen,Tien-Yau Luh +13 more
TL;DR: In this paper, the authors proposed a protocol for the synthesis of tetrahedral amorphous carbon, which can be considered as the conversion of the sp hybridised carbons into sp hybridized carbons.
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Functional Studies of ssDNA Binding Ability of MarR Family Protein TcaR from Staphylococcus epidermidis.
Yu Ming Chang,Cammy K.M. Chen,Yuan-Chih Chang,Wen Yih Jeng,Wen Yih Jeng,Ming-Hon Hou,Andrew H.-J. Wang +6 more
TL;DR: It is shown that TcaR can interact strongly with single-stranded DNA (ssDNA) and preferentially binds 33-mer ssDNA over double-strand DNA and inhibits viral ssDNA replication, suggesting a novel role in regulation of DNA replication.
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The Arginine Pairs and C-Termini of the Sso7c4 from Sulfolobus solfataricus Participate in Binding and Bending DNA.
Bo Lin Lin,Chin Yu Chen,Chun-Hsiang Huang,Tzu-Ping Ko,Cheng Hung Chiang,Kuan Fu Lin,Yuan-Chih Chang,Po Yen Lin,Hui Hsu Gavin Tsai,Andrew H.-J. Wang +9 more
TL;DR: A model of the Sso7c4-DNA complex using a curved DNA molecule in the catabolite activator protein- DNA complex is proposed and a functional role for Sso 7c4 in the organization of chromosomal DNA and/or the regulation of gene expression through bridging and bending interactions is suggested.
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Use of Cryo-EM To Uncover Structural Bases of pH Effect and Cofactor Bispecificity of Ketol-Acid Reductoisomerase.
Chin Yu Chen,Yuan-Chih Chang,B.L. Lin,K.F. Lin,Chun-Hsiang Huang,D.L. Hsieh,Tzu Ping Ko,Tsai +7 more
TL;DR: The ketol-acid reductoisomerase (KARI) catalyzes conversion of (2S)-acetolactate or ( 2S)- acetolactates to keto-EM, where the latter is converted to polymethine by the KARI machinery.