Y
Yuanfan Zhang
Researcher at Johns Hopkins University
Publications - 15
Citations - 627
Yuanfan Zhang is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Muscular dystrophy & Biology. The author has an hindex of 10, co-authored 11 publications receiving 490 citations. Previous affiliations of Yuanfan Zhang include Boston Children's Hospital & Harvard University.
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Journal ArticleDOI
Concordant but Varied Phenotypes among Duchenne Muscular Dystrophy Patient-Specific Myoblasts Derived using a Human iPSC-Based Model
In Young Choi,Ho Tae Lim,Kenneth Estrellas,Jyothi Mula,Tatiana V. Cohen,Tatiana V. Cohen,Yuanfan Zhang,Yuanfan Zhang,Christopher J. Donnelly,Jean Philippe Richard,Yong Jun Kim,Hyesoo Kim,Yasuhiro Kazuki,Mitsuo Oshimura,Hongmei Lisa Li,Akitsu Hotta,Jeffrey D. Rothstein,Nicholas J. Maragakis,Kathryn R. Wagner,Gabsang Lee +19 more
TL;DR: The findings demonstrate the feasibility of establishing a human "DMD-in-a-dish" model using hiPSC-based disease modeling and reveal concordant disease-related phenotypes with patient-dependent variation.
Journal ArticleDOI
In Vivo Selection Yields AAV-B1 Capsid for Central Nervous System and Muscle Gene Therapy
Sourav Roy Choudhury,Zachary Fitzpatrick,Anne F Harris,Stacy Maitland,Jennifer S Ferreira,Yuanfan Zhang,Shan Ma,Rohit Sharma,Heather L. Gray-Edwards,Jacob A. Johnson,Aime K. Johnson,Laura C. Alonso,Claudio Punzo,Kathryn R. Wagner,Casey A. Maguire,Robert M. Kotin,Douglas R. Martin,Miguel Sena-Esteves +17 more
TL;DR: The isolation of a novel CNS tropic AAV capsid, AAV-B1, after a single round of in vivo selection from an AAV Capsid library is reported, which represents an important improvement over AAV9 for CNS gene therapy.
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A novel electrochemical biosensor based on dynamic polymerase-extending hybridization for E. coli O157:H7 DNA detection.
TL;DR: The present approach provides low detection limit for DNA, rapid label-free and easy-to-use bacteria detection, which holds the potential for future use in various ss-DNA analyses by integrated into a self-contained biochip.
Journal ArticleDOI
Morpholino-mediated Knockdown of DUX4 Toward Facioscapulohumeral Muscular Dystrophy Therapeutics.
Jennifer C. J. Chen,Oliver D. King,Yuanfan Zhang,Yuanfan Zhang,Nicholas P. Clayton,Carrie Spencer,Bruce M. Wentworth,Charles P. Emerson,Kathryn R. Wagner +8 more
TL;DR: Findings demonstrate the potential of antisense phosphorodiamidate morpholino oligonucleotides as an FSHD therapeutic option and down-regulated many transcriptional targets of DUX4, without overt off-target effects.
Journal ArticleDOI
Human skeletal muscle xenograft as a new preclinical model for muscle disorders
Yuanfan Zhang,Oliver D. King,Fedik Rahimov,Takako I. Jones,Christopher W. Ward,Jaclyn P. Kerr,Naili Liu,Charles P. Emerson,Louis M. Kunkel,Terence A. Partridge,Kathryn R. Wagner +10 more
TL;DR: The value of a new experimental model of muscle disease, the human muscle xenograft in mice, as a feasible and valid preclinical tool to better investigate the pathogenesis of human genetic myopathies and to more accurately predict their response to novel therapeutics is illustrated.