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Yuchen Feng
Researcher at University of Michigan
Publications - 14
Citations - 8498
Yuchen Feng is an academic researcher from University of Michigan. The author has contributed to research in topics: Autophagy & Autophagosome. The author has an hindex of 10, co-authored 13 publications receiving 6789 citations. Previous affiliations of Yuchen Feng include Baylor College of Medicine.
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Journal ArticleDOI
Downregulation of autophagy by Met30-mediated Atg9 ubiquitination.
TL;DR: In this paper, a posttranslational modification of Atg9 was proposed to limit autophagy to a low, basal level during normal conditions, and then targeted for degradation in a proteasome-dependent manner through the action of E3 ligase Met30.
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Receptors make the pathway choice for protein degradation
Yuchen Feng,Daniel J. Klionsky +1 more
TL;DR: In a paper described in a punctum in this issue, Lu et al. used the yeast Saccharomyces cerevisiae to demonstrate that the decision to use a particular pathway is made through a mechanism that depends on the receptors rather than the specific type of substrate ubiquitination.
Journal ArticleDOI
Downregulation of autophagy through CUL3-KLHL20-mediated turnover of the ULK1 and PIK3C3/VPS34 complexes.
Yuchen Feng,Daniel J. Klionsky +1 more
TL;DR: A function of the CUL3-KLHL20 ubiquitin ligase in feedback regulation is reported, leading to the downregulation of autophagy through the degradation of the ULK1 and PIK3C3/VPS34 complexes.
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Aggravated renal fibrosis is positively associated with the activation of HMGB1-TLR2/4 signaling in STZ-induced diabetic mice
Yan-Hua Yuan,Yuan-Yuan Liu,Mengyao Sun,Hui-Ying Ye,Yuchen Feng,Zhenzhen Liu,Lingyu Pan,Hong-Bo Weng +7 more
TL;DR: In this paper, the authors demonstrate that the severity of renal fibrosis is positively associated with the activation of HMGB1/TLR2/4 signaling in diabetes, and that macrophage infiltration was involved in perpetuating inflammation and subsequent fibrosis in the kidneys of diabetic mice.