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Yuhai Zhao
Researcher at LSU Health Sciences Center New Orleans
Publications - 92
Citations - 4648
Yuhai Zhao is an academic researcher from LSU Health Sciences Center New Orleans. The author has contributed to research in topics: Gene expression & microRNA. The author has an hindex of 34, co-authored 83 publications receiving 3757 citations. Previous affiliations of Yuhai Zhao include University of Texas Health Science Center at Houston & University of Texas at Austin.
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Journal ArticleDOI
An NF-κB-sensitive Micro RNA-146a-mediated Inflammatory Circuit in Alzheimer Disease and in Stressed Human Brain Cells
TL;DR: Data indicate that NF-κB-sensitive miRNA-146a-mediated modulation of CFH gene expression may in part regulate an inflammatory response in AD brain and in stressed HN cell models of AD and illustrate the potential for anti-miRNAs as an effective therapeutic strategy against pathogenic inflammatory signaling.
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Secretory Products of the Human GI Tract Microbiome and Their Potential Impact on Alzheimer's Disease (AD): Detection of Lipopolysaccharide (LPS) in AD Hippocampus.
TL;DR: The presence of bacterial lipopolysaccharide (LPS) in brain lysates from the hippocampus and superior temporal lobe neocortex of Alzheimer's disease (AD) brains is reported for the first time.
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Deficiency in the Ubiquitin Conjugating Enzyme UBE2A in Alzheimer's Disease (AD) is Linked to Deficits in a Natural Circular miRNA-7 Sponge (circRNA; ciRS-7).
TL;DR: Dysfunction of circRNA-miRNA-mRNA regulatory systems appears to represent another important layer of epigenetic control over pathogenic gene expression programs in the human CNS that are targeted by the sporadic AD process.
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Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARγ-mediated mechanisms in Alzheimer's disease models.
Yuhai Zhao,Frédéric Calon,Carl Julien,Jeremy W. Winkler,Nicos A. Petasis,Walter J. Lukiw,Nicolas G. Bazan +6 more
TL;DR: NPD1 bioactivity potently down regulates inflammatory signaling, amyloidogenic APP cleavage and apoptosis, underscoring the potential of this lipid mediator to rescue human brain cells in early stages of neurodegenerations.
Journal Article
microRNA (miRNA) speciation in Alzheimer's disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF)
Peter N. Alexandrov,Prerna Dua,James M. Hill,Surjyadipta Bhattacharjee,Yuhai Zhao,Walter J. Lukiw +5 more
TL;DR: Analysis of amyloid beta peptide and micro RNA abundance in CSF and brain tissue-derived extracellular fluid from Alzheimer's disease and short post-mortem interval suggest that they may be involved in the modulation or proliferation of miRNA-triggered pathogenic signaling throughout the brain and central nervous system (CNS).