N
Nicos A. Petasis
Researcher at University of Southern California
Publications - 272
Citations - 21078
Nicos A. Petasis is an academic researcher from University of Southern California. The author has contributed to research in topics: Lipoxin & Inflammation. The author has an hindex of 76, co-authored 268 publications receiving 19503 citations. Previous affiliations of Nicos A. Petasis include Université de Montréal & University of Pennsylvania.
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Journal ArticleDOI
Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1
Makoto Arita,Francesca Bianchini,Julio Aliberti,Alan Sher,Nan Chiang,Song Hong,Rong Yang,Nicos A. Petasis,Charles N. Serhan +8 more
TL;DR: Novel counterregulatory responses in inflammation initiated via RvE1 receptor activation that provide the first evidence for EPA-derived potent endogenous agonists of antiinflammation are demonstrated.
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Resolvins and Protectins in Inflammation-Resolution
TL;DR: This review summarizes efforts on the resolvins and protectins with an emphasis on the corresponding biochemical pathways and the key role of a number of lipid mediators in the initiation of the inflammatory response and the subsequent progression towards resolution.
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Resolvin D1 binds human phagocytes with evidence for proresolving receptors
Sriram Krishnamoorthy,Antonio Recchiuti,Nan Chiang,Stephanie Yacoubian,Chih-Hao Lee,Rong Yang,Nicos A. Petasis,Charles N. Serhan +7 more
TL;DR: It is demonstrated that RvD1 actions on human polymorphonuclear leukocytes (PMNs) are pertussis toxin sensitive, decrease actin polymerization, and block LTB4-regulated adhesion molecules (β2 integrins).
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Cutting edge: lipoxins rapidly stimulate nonphlogistic phagocytosis of apoptotic neutrophils by monocyte-derived macrophages.
TL;DR: It is suggested that LXA4 is an endogenous stimulus for PMN clearance during inflammation and provide a novel rationale for using stable synthetic analogues as anti-inflammatory compounds in vivo.
Journal ArticleDOI
Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis
Matthew Spite,Lucy V. Norling,Lucy V. Norling,Lisa Summers,Rong Yang,Dianne Cooper,Nicos A. Petasis,Roderick J. Flower,Mauro Perretti,Charles N. Serhan +9 more
TL;DR: This work identifies RvD2 as a potent endogenous regulator of excessive inflammatory responses that acts via multiple cellular targets to stimulate resolution and preserve immune vigilance in mice with microbial sepsis induced by caecal ligation and puncture and surgery.