Y
Yujiro Hayashi
Researcher at Osaka University
Publications - 112
Citations - 3830
Yujiro Hayashi is an academic researcher from Osaka University. The author has contributed to research in topics: Interstitial cell of Cajal & Ghrelin. The author has an hindex of 29, co-authored 110 publications receiving 3309 citations. Previous affiliations of Yujiro Hayashi include Mayo Clinic & Daiichi Sankyo.
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Hemodynamic and hormonal effects of human ghrelin in healthy volunteers
Noritoshi Nagaya,Masayasu Kojima,Masaaki Uematsu,Masakazu Yamagishi,Hiroshi Hosoda,Hideo Oya,Yujiro Hayashi,Kenji Kangawa +7 more
TL;DR: Human ghrelin elicited a potent, long-lasting GH release and had beneficial hemodynamic effects via reducing cardiac afterload and increasing cardiac output without an increase in heart rate.
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Structure–Activity Relationship of Ghrelin: Pharmacological Study of Ghrelin Peptides
Masaru Matsumoto,Hiroshi Hosoda,Yasuo Kitajima,Naomi Morozumi,Yoshiharu Minamitake,Shoji Ashiya-shi Tanaka,Hisayuki Matsuo,Masayasu Kojima,Yujiro Hayashi,Kenji Kangawa +9 more
TL;DR: More stable ether or thioether bonds are capable of replacing the octanoyl ester bond in ghrelin, advantageous for the generation of pharmaceuticals with longer stability.
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C-type natriuretic peptide is a growth inhibitor of rat vascular smooth muscle cells.
Mayumi Furuya,Maki Yoshida,Yujiro Hayashi,Norio Ohnuma,Naoto Minamino,Kenji Kangawa,Hisayuki Matsuo +6 more
TL;DR: CNP may be a growth regulating factor of VSMC rather than a vasodilator, and the peptide was less active for cGMP augmentation and for vasorelaxation than alpha-hANP in isolated rat aorta.
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Anti-cachectic effect of ghrelin in nude mice bearing human melanoma cells
Takeshi Hanada,Koji Toshinai,Naoko Kajimura,Noriko Nara-Ashizawa,Toshihiko Tsukada,Yujiro Hayashi,Kazuhiro Osuye,Kenji Kangawa,Shigeru Matsukura,Masamitsu Nakazato +9 more
TL;DR: The anabolic effect of ghrelin efficiently reverses the cachexia in mice bearing SEKI human melanoma and may have a therapeutic ability to ameliorate cancer cachexia.
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Topical Implantation of Mesenchymal Stem Cells Has Beneficial Effects on Healing of Experimental Colitis in Rats
Yujiro Hayashi,Shingo Tsuji,Masahiko Tsujii,Tsutomu Nishida,Shuji Ishii,Hideki Iijima,Toru Nakamura,Hiroshi Eguchi,Eiji Miyoshi,Norio Hayashi,Sunao Kawano +10 more
TL;DR: It is found that MSCs were successfully topically implanted in the colon and that they were associated with accelerated healing of TNBS-induced colitis, which might be mediated, at least in part, by their able to differentiate into colonic interstitial cells and by their ability to provide VEGF and TGF-β1 to the injured area.