Y
Yuka Sasaki
Researcher at Showa University
Publications - 13
Citations - 444
Yuka Sasaki is an academic researcher from Showa University. The author has contributed to research in topics: Prostacyclin & Prostaglandin E. The author has an hindex of 8, co-authored 13 publications receiving 362 citations.
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Journal ArticleDOI
Prostaglandin E synthases: Understanding their pathophysiological roles through mouse genetic models.
TL;DR: The current understanding of the in vivo roles of PGES enzymes by knockout mouse studies is summarized and an overview of their biochemical properties is provided.
Journal ArticleDOI
Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis.
Yuka Sasaki,Daisuke Kamei,Yukio Ishikawa,Toshiharu Ishii,Satoshi Uematsu,Shizuo Akira,Makoto Murakami,Makoto Murakami,Shuntaro Hara +8 more
TL;DR: The inhibition of mPGES-1 is an alternative therapeutic target for colorectal and possibly other cancers and its role in pro-tumorigenic role is shown to be important for the growth of adjacent tumor cells.
Journal ArticleDOI
Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis
Daisuke Kamei,Makoto Murakami,Makoto Murakami,Makoto Murakami,Yuka Sasaki,Yoshihito Nakatani,Masataka Majima,Yukio Ishikawa,Toshiharu Ishii,Satoshi Uematsu,Shizuo Akira,Shuntaro Hara,Ichiro Kudo +12 more
TL;DR: It is found that siRNA (small interfering RNA) silencing of mPGES-1 in LLC cells decreased PGE2 synthesis markedly, accompanied by reduced cell proliferation, attenuated Matrigel™ invasiveness and increased extracellular matrix adhesion.
Journal ArticleDOI
Role of long-chain acyl-coenzyme A synthetases in the regulation of arachidonic acid metabolism in interleukin 1β-stimulated rat fibroblasts
Hiroshi Kuwata,Makiko Yoshimura,Yuka Sasaki,Emiko Yoda,Yoshihito Nakatani,Ichiro Kudo,Shuntaro Hara +6 more
TL;DR: Results suggest that Acsl isozymes play distinct roles in the control of AA remodeling in rat fibroblasts: Acsl4 acts as the first step of enzyme forAA remodeling following IL-1β stimulation, and Acsl1 is involved in the maintenance of some AA-containing PC species.
Journal ArticleDOI
Role of microsomal prostaglandin E synthase-1 (mPGES-1)-derived prostaglandin E2 in colon carcinogenesis.
TL;DR: The current understanding of the roles of mPGES-1, a P GE2-inactivating enzyme (15-hydroxyprostagladin dehydrogenase), and PGE2 specific receptors (EPs) in colon carcinogenesis is summarized.