Y
Yuki Kishimoto
Researcher at National Institutes of Health
Publications - 4
Citations - 641
Yuki Kishimoto is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Dopaminergic & Parkinson's disease. The author has an hindex of 4, co-authored 4 publications receiving 339 citations.
Papers
More filters
Journal ArticleDOI
Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model.
Peisu Zhang,Yuki Kishimoto,Ioannis Grammatikakis,Kamalvishnu P. Gottimukkala,Roy G. Cutler,Shiliang Zhang,Kotb Abdelmohsen,Vilhelm A. Bohr,Jyoti Misra Sen,Jyoti Misra Sen,Myriam Gorospe,Mark P. Mattson,Mark P. Mattson +12 more
TL;DR: A role for Aβ-induced OPC cell senescence in neuroinflammation and cognitive deficits in AD is suggested, and a potential therapeutic benefit of senolytic treatments is suggested.
Journal ArticleDOI
SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice
Yong Liu,Aiwu Cheng,Yu Jiao Li,Yu Jiao Li,Ying Yang,Yuki Kishimoto,Shi Zhang,Yue Wang,Ruiqian Wan,Sophia M. Raefsky,Daoyuan Lu,Takashi Saito,Takaomi C. Saido,Jian Zhu,Long Jun Wu,Mark P. Mattson,Mark P. Mattson +16 more
TL;DR: It is shown that hippocampal neuronal networks adapt to IF by enhancing GABAergic tone, which is associated with reduced anxiety-like behaviors and improved hippocampus-dependent memory, and a role for a mitochondrial protein deacetylase in hippocampal neurons in behavioral and GABAergic synaptic adaptations to IF is demonstrated.
Journal ArticleDOI
Chronic Mild Gut Inflammation Accelerates Brain Neuropathology and Motor Dysfunction in α-Synuclein Mutant Mice.
Yuki Kishimoto,Wandi Zhu,Waki Hosoda,Jyoti Misra Sen,Jyoti Misra Sen,Mark P. Mattson,Mark P. Mattson +6 more
TL;DR: It is reported that chronic mild focal intestinal inflammation accelerates the age of disease onset in α-synuclein mutant PD mice and interventions that reduce gut inflammation may prove beneficial in the prevention and treatment of PD.
Journal ArticleDOI
A mitochondrial uncoupler prodrug protects dopaminergic neurons and improves functional outcome in a mouse model of Parkinson's disease.
Yuki Kishimoto,Joshua C. Johnson,William Fang,Joshua Halpern,Krisztina Marosi,Dong Liu,John G. Geisler,Mark P. Mattson,Mark P. Mattson +8 more
TL;DR: It is found that mice treated with low doses of DNP and MP201 were protected against motor dysfunction and dopamine neuron loss in the 6-hydroxydopamine PD model, with MP201 being more efficacious than DNP.