Shiliang Zhang

TL;DR: A role for Aβ-induced OPC cell senescence in neuroinflammation and cognitive deficits in AD is suggested, and a potential therapeutic benefit of senolytic treatments is suggested.

TL;DR: An unanticipated type of VTA neuron is revealed that cotransmits glutamate and GABA and provides the majority of mesohabenular inputs in LHb neurons.

TL;DR: A complex type of signaling by mesoaccumbens fibers is revealed in which dopamine and glutamate can be released from the same axons, but are not normally released at the same site or from theSame synaptic vesicles.

TL;DR: The ventral tegmental area (VTA) is best known for its dopamine neurons, some of which project to nucleus accumbens (nAcc), but the VTA also has glutamatergic neurons that project to nAcc, and the mesoaccumbens glutamatorgic pathways are reported on, which are the first glutamaters to be shown to mediate aversion instead of reward.

TL;DR: Findings indicate that the DR-VGluT3 pathway to VTA utilizes glutamate as a neurotransmitter and is a substrate linking the DR—one of the most sensitive reward sites in the brain—to VTA dopaminergic neurons.