Y
Yuki Miyasaka
Researcher at Nagoya University
Publications - 28
Citations - 245
Yuki Miyasaka is an academic researcher from Nagoya University. The author has contributed to research in topics: Gene & Hearing loss. The author has an hindex of 8, co-authored 21 publications receiving 171 citations. Previous affiliations of Yuki Miyasaka include Institute of Medical Science & Niigata University.
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Journal ArticleDOI
SDR9C7 catalyzes critical dehydrogenation of acylceramides for skin barrier formation.
Takuya Takeichi,Tetsuya Hirabayashi,Yuki Miyasaka,Akane Kawamoto,Yusuke Okuno,S. Taguchi,Kana Tanahashi,Chiaki Murase,Hiroyuki Takama,K. Tanaka,William E. Boeglin,Calcutt Mw,Daisuke Watanabe,Michihiro Kono,Yoshinao Muro,Junko Ishikawa,Tamio Ohno,Alan R. Brash,Masashi Akiyama +18 more
TL;DR: It is proposed that the critical requirement for lipoxygenases and SDR9C7 is in producing acylceramide containing the 9,10-epoxy-11E-13-ketone, a reactive moiety known for its non-enzymatic coupling to protein.
Journal ArticleDOI
Advantages of a mouse model for human hearing impairment.
Yoshiaki Kikkawa,Yuta Seki,Kazuhiro Okumura,Yasuhiro Ohshiba,Yasuhiro Ohshiba,Yuki Miyasaka,Yuki Miyasaka,Sari Suzuki,Sari Suzuki,Mao Ozaki,Mao Ozaki,Kunie Matsuoka,Yoshihiro Noguchi,Hiromichi Yonekawa +13 more
TL;DR: This review discusses the advantages of the mouse models of human hearing impairment and highlights the identification of the molecules required for stereocilia development in the inner ear hair cells by analysis of various mouse mutants.
Journal ArticleDOI
Compound heterozygosity of the functionally null Cdh23(v-ngt) and hypomorphic Cdh23(ahl) alleles leads to early-onset progressive hearing loss in mice.
Yuki Miyasaka,Sari Suzuki,Sari Suzuki,Yasuhiro Ohshiba,Yasuhiro Ohshiba,Kei Watanabe,Kei Watanabe,Yoshihiko Sagara,Shumpei P. Yasuda,Kunie Matsuoka,Hiroshi Shitara,Hiromichi Yonekawa,Ryo Kominami,Yoshiaki Kikkawa +13 more
TL;DR: Findings indicate that CDH23 plays an important role in the maintenance of tip links during the aging process, and hypothesize that the reduction of Cdh23 gene dosage in Cdh 23v-ngt/ahl mice leads to the degeneration of stereocilia, which consequently reduces tip link tension.
Journal ArticleDOI
Heterozygous mutation of Ush1g/Sans in mice causes early-onset progressive hearing loss, which is recovered by reconstituting the strain-specific mutation in Cdh23
Yuki Miyasaka,Hiroshi Shitara,Sari Suzuki,Sachi Yoshimoto,Sachi Yoshimoto,Yuta Seki,Yasuhiro Ohshiba,Kazuhiro Okumura,Choji Taya,Hisashi Tokano,Ken Kitamura,Toyoyuki Takada,Hiroshi Hibino,Toshihiko Shiroishi,Ryo Kominami,Hiromichi Yonekawa,Yoshiaki Kikkawa +16 more
TL;DR: In this article, a mouse model of recessive deafness that exhibits congenital profound deafness caused by the homozygous mutation of Ush1g/Sans on chromosome 11 was presented.
Journal ArticleDOI
A novel splice site mutation of myosin VI in mice leads to stereociliary fusion caused by disruption of actin networks in the apical region of inner ear hair cells.
Yuta Seki,Yuki Miyasaka,Yuki Miyasaka,Sari Suzuki,Kenta Wada,Kenta Wada,Shumpei P. Yasuda,Kunie Matsuoka,Yasuhiro Ohshiba,Kentaro Endo,Rie Ishii,Hiroshi Shitara,Shin-ichiro Kitajiri,Naomi Nakagata,Hirohide Takebayashi,Yoshiaki Kikkawa +15 more
TL;DR: Analysis of data indicated that decreased MYO6 levels in ksv/ksv mutants disrupt actin networks in the apical region of hair cells, thereby maintaining the normal structure of the cuticular plates and rootlets, and additionally provided a cellular basis for stereociliary fusion in Myo6 mutants.